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This study utilized PET imaging to determine whether abnormalities in brain dopamine (DA) similar to those described in substance use disorders occur in BN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p>PET imaging with [<jats:sup>11<\/jats:sup>C]raclopride, pre\/post methylphenidate administration, to assess dopamine type 2 (D<jats:sub>2<\/jats:sub>) receptor binding (BP<jats:sub>ND<\/jats:sub>) and striatal DA release (\u0394BP<jats:sub>ND<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>There was a trend toward lower D<jats:sub>2<\/jats:sub>receptor BP<jats:sub>ND<\/jats:sub>in two striatal subregions in the patient group when compared with the control group. DA release in the putamen in the patient group was significantly reduced and, overall, there was a trend toward a difference in striatal DA release. Striatal DA release was significantly associated with the frequency of binge eating.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion:<\/jats:title><jats:p>These data suggest that BN is characterized by abnormalities in brain DA that resemble, in some ways, those described in addictive disorders. \u00a9 2012 by Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.20984","type":"journal-article","created":{"date-parts":[[2012,2,13]],"date-time":"2012-02-13T11:50:42Z","timestamp":1329133842000},"page":"648-656","source":"Crossref","is-referenced-by-count":81,"title":["Striatal dopamine in bulimia nervosa: A pet imaging study"],"prefix":"10.1002","volume":"45","author":[{"given":"Allegra","family":"Broft","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Shingleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dileep","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Slifstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anissa","family":"Abi\u2010Dargham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Schebendach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Van Heertum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Attia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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