{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:57:40Z","timestamp":1792144660137,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T00:00:00Z","timestamp":1348444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Given that atypical antipsychotic medications have been increasingly prescribed for improving weight gain in anorexia nervosa (AN), we conducted a systematic review and meta\u2010analyses to estimate the influence of atypical antipsychotics on BMI, eating disorder, and psychiatric symptoms in individuals with AN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>Independent reviewers selected studies and extracted study characteristics, methodologic quality, and outcomes for the intention\u2010to\u2010treat group from randomized clinical trials comparing the effect of atypical antipsychotic use to placebo or an active control treatment on BMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Compared with placebo, atypical antipsychotics were associated with a nonsignificant increase in BMI (weighted mean difference, WMD = 0.18, 95% CI: \u22120.36, 0.72;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 26%) and a nonsignificant effect on the drive for thinness and body dissatisfaction. Compared with placebo or active control, these medications led to an increase in anxiety and overall eating disorder symptoms. However, there was a significant reduction over placebo or active control on level of depression. \u00a9 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2013)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.22059","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T05:32:35Z","timestamp":1348464755000},"page":"332-339","source":"Crossref","is-referenced-by-count":89,"title":["The effect of atypical antipsychotic medications in individuals with anorexia nervosa: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"46","author":[{"given":"Jocelyn","family":"Lebow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia J.","family":"Erwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Hassan","family":"Murad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.yco.0000228759.95237.78"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.8.1284"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20109"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2010.03.011"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.11.1686"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711000390"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2011.06.009"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20576"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-004-0509-y"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.5.790"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.5.947"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043384088"},{"key":"e_1_2_5_15_2","first-page":"207","article-title":"A placebo\u2010controlled pilot study of adjunctive olanzapine for adolescents with anorexia nervosa","volume":"21","author":"Kafantaris V","year":"2011","journal-title":"J Child Adolesc Psychiatr Ment Health Nurs"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1469"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.2174\/157488610789869265"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7382.219"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2007.02.005"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e328080ca31"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.07121900"},{"key":"e_1_2_5_24_2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1080\/j.1440-1665.2004.02154.x","article-title":"Randomized controlled trial of olanzapine in the treatment of cognitions in anorexia nervosa","volume":"13","author":"Mondraty N","year":"2005","journal-title":"Australas Psychiatry"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(01)00174-9"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H297"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200427140-00005"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/erv.988"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feat.22059","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.22059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T08:59:34Z","timestamp":1700643574000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.22059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,24]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1002\/eat.22059"],"URL":"https:\/\/doi.org\/10.1002\/eat.22059","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717958763.793462959","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.717958763.793464045","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.717958763.793464208","asserted-by":"object"}]},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,24]]}}}