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Outcome measures of binge eating, body weight, and eating pathology were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>A large decrease in binge eating episode frequency was observed following both ALKS\u201033 and placebo treatment. There was no significant difference between treatment groups in binge eating episode frequency or any other measure of binge eating, body weight, or eating pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion:<\/jats:title><jats:p>In this preliminary proof\u2010of\u2010concept study in BED, ALKS\u201033 did not separate from placebo. Although a failed trial cannot be excluded, the finding is consistent with earlier observations in bulimia nervosa with other opioid antagonists and suggests ALKS\u201033, at least when administered daily for 6 weeks, may not be efficacious for BED. \u00a9 2013 by Wiley Periodicals, Inc. 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