{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:53:35Z","timestamp":1790481215573,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T00:00:00Z","timestamp":1367193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Milano-Bicocca, Italy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Altered expression and\/or function, both peripherally and centrally, of various neuropeptides is involved in the neurophysiology of anorexia nervosa (AN). Diazepam\u2010binding inhibitor (DBI) is an interesting peptide for understanding this crosstalk. The aim of this work was to assess fasting plasma levels of DBI and leptin in patients with AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Twenty\u2010four AN adolescents were recruited together with 10 age\u2010comparable healthy controls. Neuropeptide determinations were performed on plasma samples by enzyme\u2010linked immunosorbent assays. Patients with AN were further characterized for the presence of a depressive state or anxiety by using, respectively, the Children's Depression Inventory or the State\u2010Trait Anxiety Inventory form Y.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Levels of both plasma DBI and leptin were reduced in patients with AN (\u223c40 and \u223c70%, respectively). DBI levels displayed a tendency to increase in the presence of a depressive state, although not with anxiety, whereas leptin levels correlated exclusively with body mass index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These data further extend our knowledge of neuropeptide dysfunction in AN, and plasma DBI may represent a marker for this disease, in particular considering its correlation with comorbid mood disorders. \u00a9 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:626\u2013629)<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.22129","type":"journal-article","created":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T08:58:47Z","timestamp":1367225927000},"page":"626-629","source":"Crossref","is-referenced-by-count":19,"title":["Reduced fasting plasma levels of diazepam\u2010binding inhibitor in adolescents with anorexia nervosa"],"prefix":"10.1002","volume":"46","author":[{"given":"Elisa","family":"Conti","sequence":"first","affiliation":[{"name":"Neurology and Laboratory of Neurobiology University of Milano\u2010Bicocca, San Gerardo Hospital Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Tremolizzo","sequence":"additional","affiliation":[{"name":"Neurology and Laboratory of Neurobiology University of Milano\u2010Bicocca, San Gerardo Hospital Monza 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