{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:56:07Z","timestamp":1787597767109,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T00:00:00Z","timestamp":1365465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AA07535"],"award-info":[{"award-number":["AA07535"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AA07728"],"award-info":[{"award-number":["AA07728"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AA13320"],"award-info":[{"award-number":["AA13320"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AA13321"],"award-info":[{"award-number":["AA13321"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AA14041"],"award-info":[{"award-number":["AA14041"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AA11998"],"award-info":[{"award-number":["AA11998"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AA17688"],"award-info":[{"award-number":["AA17688"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DA012854"],"award-info":[{"award-number":["DA012854"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DA019951"],"award-info":[{"award-number":["DA019951"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Australian National Health and Medical Research Council","award":["241944"],"award-info":[{"award-number":["241944"]}]},{"name":"Australian National Health and Medical Research Council","award":["339462"],"award-info":[{"award-number":["339462"]}]},{"name":"Australian National Health and Medical Research Council","award":["389927"],"award-info":[{"award-number":["389927"]}]},{"name":"Australian National Health and Medical Research Council","award":["389875"],"award-info":[{"award-number":["389875"]}]},{"name":"Australian National Health and Medical Research Council","award":["389891"],"award-info":[{"award-number":["389891"]}]},{"name":"Australian National Health and Medical Research Council","award":["389892"],"award-info":[{"award-number":["389892"]}]},{"name":"Australian National Health and Medical Research Council","award":["389938"],"award-info":[{"award-number":["389938"]}]},{"name":"Australian National Health and Medical Research Council","award":["442915"],"award-info":[{"award-number":["442915"]}]},{"name":"Australian National Health and Medical Research Council","award":["442981"],"award-info":[{"award-number":["442981"]}]},{"name":"Australian National Health and Medical Research Council","award":["496739"],"award-info":[{"award-number":["496739"]}]},{"name":"Australian National Health and Medical Research Council","award":["552485"],"award-info":[{"award-number":["552485"]}]},{"name":"Australian National Health and Medical Research Council","award":["552498"],"award-info":[{"award-number":["552498"]}]},{"name":"5th Framework Programme (FP-5) GenomEUtwin Project","award":["QLG2-CT-2002-01254"],"award-info":[{"award-number":["QLG2-CT-2002-01254"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Although the genetic contribution to the development of anorexia nervosa (AN) has long been recognized, there has been little progress relative to other psychiatric disorders in identifying specific susceptibility genes. Here, we have carried out a genome\u2010wide association study on an unselected community sample of female twins surveyed for eating disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We conducted genome\u2010wide association analyses in 2,564 female twins for four different phenotypes derived from self\u2010report data relating to lifetime presence of 15 types of disordered eating: AN spectrum, bulimia nervosa (BN) spectrum, purging via substances, and a binary measure of no disordered eating behaviors versus three or more. To complement the variant level results, we also conducted gene\u2010based association tests using VEGAS software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Although no variants reached genome\u2010wide significance at the level of\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 10\n                      <jats:sup>\u22128<\/jats:sup>\n                      , six regions were suggestive (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 5 \u00d7 10\n                      <jats:sup>\u22127<\/jats:sup>\n                      ). The current results implicate the following genes: CLEC5A, LOC136242, TSHZ1, and SYTL5 for the AN spectrum phenotype; NT5C1B for the BN spectrum phenotype; and ATP8A2 for the disordered eating behaviors phenotype.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>As with other medical and psychiatric phenotypes, much larger samples and meta\u2010analyses will ultimately be needed to identify genes and pathways contributing to predisposition to eating disorders. \u00a9 2013 by Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:594\u2013608)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.22133","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T06:20:21Z","timestamp":1365488421000},"page":"594-608","source":"Crossref","is-referenced-by-count":64,"title":["Genetic variants associated with disordered eating"],"prefix":"10.1002","volume":"46","author":[{"given":"Tracey D.","family":"Wade","sequence":"first","affiliation":[{"name":"School of Psychology Flinders University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Genetic Epidemiology Queensland Institute of Medical Research Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Medland","sequence":"additional","affiliation":[{"name":"Department of Genetic Epidemiology Queensland Institute of Medical Research Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia M.","family":"Bulik","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of North Carolina Chapel Hill North Carolina"},{"name":"Department of Nutrition University of North Carolina Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Heath","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant W.","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Department of Genetic Epidemiology Queensland Institute of Medical Research Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Genetic Epidemiology Queensland Institute of Medical Research Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.3.469"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.3.305"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291799008740"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1995.03950170048007"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00280-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/339250"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.6.689"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001318"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/345801"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2009.74"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.107"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32087"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-011-1118-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-009-0085-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09020247"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.173.1.11"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.7.1073"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.054742"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08040608"},{"key":"e_1_2_6_21_1","first-page":"125","volume-title":"A Collaborative Approach to Eating Disorders","author":"Wade TD","year":"2011"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.11.029"},{"key":"e_1_2_6_23_1","article-title":"The genetic architecture of psychiatric disorders: Apprehending the outline, glimpsing the details","author":"Sullivan PF","journal-title":"Nat Rev Genet"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291701004901"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-108X(199601)19:1<63::AID-EAT8>3.0.CO;2-U"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1375\/1369052012182"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.nmd.0000225067.42191.b0"},{"key":"e_1_2_6_28_1","first-page":"317","volume-title":"Binge Eating: Nature, Assessment and Treatment","author":"Fairburn CG","year":"1993"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/00048679709065511"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2354"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng786"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.06.009"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.04.007"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016729"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3240"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20668"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feat.22133","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feat.22133","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.22133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T03:36:49Z","timestamp":1696563409000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.22133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,9]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1002\/eat.22133"],"URL":"https:\/\/doi.org\/10.1002\/eat.22133","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,9]]}}}