{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:33:32Z","timestamp":1780468412746,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:00:00Z","timestamp":1372291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This case report describes a 26\u2010year\u2010old woman affected by long\u2010lasting anorexia nervosa (AN) and Crohn's disease. Worsening of the bowel illness led to the prescription of immunosuppressive therapy (biologic infliximab for 4 months, followed by adalimumab for 6 months) and referral to our Eating Disorders Unit. Although she initially demonstrated denial of her eating disorder, in a few months she gradually improved her weight and psychopathology. Crohn's disease can worsen AN by modifying hunger and energy expenditure through the effects of TNF\u2010\u03b1 and IL\u20106, pro\u2010inflammatory cytokines which moderate leptin and melanocortin signaling. Previous studies have observed the antidepressant effects of TNF antagonist in patients with treatment\u2010resistant depression with high baseline inflammatory biomarkers. Our case report suggests that future studies are needed to clarify the existence, patterns, and extent of increased inflammatory markers in patients with AN, and whether they determine clinical features or identify subgroups of patients. Potential therapeutic significance of above issues remains to be determined. \u00a9 2013 Wiley Periodicals, Inc.(Int J Eat Disord 2013; 46:639\u2013641)<\/jats:p>","DOI":"10.1002\/eat.22153","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T11:42:47Z","timestamp":1372333367000},"page":"639-641","source":"Crossref","is-referenced-by-count":44,"title":["A case of anorexia nervosa with comorbid Crohn's disease: Beneficial effects of anti\u2010TNF\u2010\u03b1 therapy?"],"prefix":"10.1002","volume":"46","author":[{"given":"Marco","family":"Solmi","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Santonastaso","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Caccaro","sequence":"additional","affiliation":[{"name":"Department of Surgery Oncology and Gastroenterology University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Favaro","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,27]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291796004394"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.4.566"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.3.298"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0409"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1580-8"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-9877(96)90153-X"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(02)00021-5"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-008-9118-1"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamapsychiatry.4"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb03190.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00230-9"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2011.02158.x"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000944"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.4.1226"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000026606"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feat.22153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feat.22153","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.22153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T07:37:39Z","timestamp":1696577859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.22153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,27]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1002\/eat.22153"],"URL":"https:\/\/doi.org\/10.1002\/eat.22153","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,27]]}}}