{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:05:42Z","timestamp":1776870342187,"version":"3.51.2"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T00:00:00Z","timestamp":1374710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess preliminarily the effectiveness of zonisamide in bulimia nervosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was an open\u2010label, prospective, 12\u2010week, flexible dose study of zonisamide in bulimia nervosa. The primary outcome was binge\u2010purge episode frequency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve individuals received zonisamide, 10 completed at least one post\u2010baseline evaluation, and six completed the study. Mean dose at endpoint was 420 (SD\u2009=\u2009215) mg\/day. Zonisamide was associated with significant reductions in frequency of binge\u2010purge episodes and binge\u2010purge days as well as measures of binge eating behavior, purging behavior, clinical severity, obsessive\u2010compulsive features, and depressive symptoms. Weight was unchanged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In this open\u2010label trial, zonisamide was effective in bulimia nervosa, but associated with a high discontinuation rate. \u00a9 2013 Wiley Periodicals, Inc. <jats:bold><jats:italic>(Int J Eat Disord 2013; 46:747\u2013750)<\/jats:italic><\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.22159","type":"journal-article","created":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T17:29:21Z","timestamp":1374773361000},"page":"747-750","source":"Crossref","is-referenced-by-count":13,"title":["Zonisamide in the treatment of bulimia nervosa: An open\u2010label, pilot, prospective study"],"prefix":"10.1002","volume":"46","author":[{"given":"Anna I.","family":"Guerdjikova","sequence":"first","affiliation":[{"name":"Lindner Center of HOPE Mason Ohio"},{"name":"Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine Cincinnati 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