{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:08:58Z","timestamp":1761919738056},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T00:00:00Z","timestamp":1374537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Anorexia nervosa (AN) is a serious disorder that is associated with numerous medical complications and affects both females and males. Severely elevated transaminases have been reported in adult and younger females. We report the first case of elevated transaminases in an adolescent male with AN. The pathophysiologic mechanism of severely elevated serum transaminases observed in malnourished adolescent males with AN is complex and appears to be multifactorial. We present the first case of an adolescent male with AN who developed severely elevated serum transaminases that normalized with improved nutrition and weight gain. Liver injury in patients with AN is a complex medical complication that appears to be multifactorial in origin. In this case, starvation\u2010induced autophagy in the human liver was considered one of the most likely mechanisms to explain hepatocytic injury in this patient. \u00a9 2013 Wiley Periodicals, Inc. <jats:bold><jats:italic>(Int J Eat Disord 2013; 46:751\u2013754)<\/jats:italic><\/jats:bold><\/jats:p>","DOI":"10.1002\/eat.22162","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T14:06:49Z","timestamp":1374674809000},"page":"751-754","source":"Crossref","is-referenced-by-count":12,"title":["Severely elevated transaminases in an adolescent male with anorexia nervosa"],"prefix":"10.1002","volume":"46","author":[{"given":"Ryan W.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of General Paediatrics, The Hospital for Sick Children University of Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chana","family":"Korenblum","sequence":"additional","affiliation":[{"name":"Division of Adolescent Medicine, Department of Paediatrics, The Hospital for Sick Children University of Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunal","family":"Thacker","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, The Hospital for Sick Children University of Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert Joey","family":"Bonifacio","sequence":"additional","affiliation":[{"name":"Division of Adolescent Medicine, Department of Paediatrics, The Hospital for Sick Children University of Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Gonska","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, The Hospital for Sick Children University of Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra K.","family":"Katzman","sequence":"additional","affiliation":[{"name":"Division of Adolescent Medicine, Department of Paediatrics, The Hospital for Sick Children University of Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,23]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Diagnostic and statistical manual of mental disorders: DSM\u2010IV\u2010TR","author":"American Psychiatric Association","year":"2000"},{"key":"e_1_2_5_3_1","unstructured":"MineT OgataE KumanoH KubokiT SuematsuH.Liver dysfunction in anorexia nervosa.Reports of the anorexia nervosa study group sponsored by the Japanese Ministry of Health and Welfare1991;129\u2013131."},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.38.575"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2006.01.003"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/eat.20002","article-title":"Acute liver damage in anorexia nervosa","volume":"36","author":"Pascoli L","year":"2004","journal-title":"Int J Eat Disord"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20775"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20690"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005642601144"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1845-7"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcpc1110053"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.47.0824"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.08.020"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.37.32"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1205406"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.055"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20889"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01006.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.03.006"},{"key":"e_1_2_5_20_1","first-page":"299","article-title":"Pharmacological trial of concentrated crude extract of stevia rebudiana (Bert.) 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