{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:56:05Z","timestamp":1789642565062,"version":"4.0.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T00:00:00Z","timestamp":1374537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Starvation\u2010induced depletion of fat stores in anorexia nervosa (AN) is known to be accompanied by alterations in some circulating adipocytokines. We analyzed a panel of circulating adipocytokines in women with AN compared with normal\u2010weight controls and their relation with the disease duration and weight restoration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We analyzed circulating adipocytokine levels in 28 patients with AN and in 33 normal\u2010weight controls who were eating healthily. We determined by enzyme\u2010linked immunosorbent assay the circulating levels of total and high molecular weight (HMW) adiponectin, lipocalin\u20102 (LCN2), leptin, tumor necrosis factor receptor\u2010II (TNFRII), interleukin\u20106 (IL6), adipocyte fatty acid binding protein\u20104 (FABP4), ghrelin, and resistin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The two circulating forms of adiponectin are higher in AN women compared with controls. Both total and HMW adiponectin related negatively to the duration of the disease (<jats:italic>r<\/jats:italic> = \u22120.372, <jats:italic>p<\/jats:italic> = 0.033; <jats:italic>r<\/jats:italic> = \u22120.450, <jats:italic>p<\/jats:italic> = 0.038, respectively). Furthermore, the lipid binding\u2010proteins LCN2 and FABP4 are lower in AN compared to the control group. Finally, leptin levels are lower in AN against controls and correlated positively with disease duration (<jats:italic>r<\/jats:italic> = 0.537, <jats:italic>p<\/jats:italic> = 0.007). Resistin, ghrelin, TNFRII, and IL6 have similar values in both groups, although TNFRII and ghrelin related negatively to body mass index variation at the end of treatment (<jats:italic>r<\/jats:italic> = \u22120.456, <jats:italic>p<\/jats:italic> = 0.039; <jats:italic>r<\/jats:italic> = \u22120.536, <jats:italic>p<\/jats:italic> = 0.015, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These results suggest there is a need to investigate if changes in adipocytokine levels could serve as weight restoration biomarkers. Further studies are warranted to elucidate the specific role of these molecules in the timing of weight restoration. \u00a9 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:855\u2013861)<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.22166","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T14:06:58Z","timestamp":1374674818000},"page":"855-861","source":"Crossref","is-referenced-by-count":40,"title":["Adipocytokine levels in women with anorexia nervosa. Relationship with weight restoration and disease duration"],"prefix":"10.1002","volume":"46","author":[{"given":"Ximena","family":"Terra","sequence":"first","affiliation":[{"name":"Grup d'estudi de malalties metab\u00f2liques associades a insulin resist\u00e8ncia (GEMMAIR) Hospital Universitari de Tarragona Joan XXIII, IISPV Universitat Rovira i Virgili Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Auguet","sequence":"additional","affiliation":[{"name":"Grup d'estudi de malalties metab\u00f2liques associades a insulin resist\u00e8ncia (GEMMAIR) Hospital Universitari de Tarragona Joan XXIII, IISPV Universitat Rovira i Virgili Tarragona Spain"},{"name":"Servei Medicina Interna, Hospital Universitari Joan XXIII Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaida","family":"Ag\u00fcera","sequence":"additional","affiliation":[{"name":"CIBER, Fisiopatolog\u00eda de la Obesidad y Nutricion (CIBERObn), Instituto Carlos III  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel Maria","family":"Quesada","sequence":"additional","affiliation":[{"name":"Grup d'estudi de malalties metab\u00f2liques associades a insulin resist\u00e8ncia (GEMMAIR) Hospital Universitari de Tarragona Joan XXIII, IISPV Universitat Rovira i Virgili Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep Maria","family":"Orellana\u2010Gavald\u00e0","sequence":"additional","affiliation":[{"name":"Grup d'estudi de malalties metab\u00f2liques associades a insulin resist\u00e8ncia (GEMMAIR) Hospital Universitari de Tarragona Joan XXIII, IISPV Universitat Rovira i Virgili Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Grup d'estudi de malalties metab\u00f2liques associades a insulin resist\u00e8ncia (GEMMAIR) Hospital Universitari de Tarragona Joan XXIII, IISPV Universitat Rovira i Virgili Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Jim\u00e9nez\u2010Murcia","sequence":"additional","affiliation":[{"name":"CIBER, Fisiopatolog\u00eda de la Obesidad y Nutricion (CIBERObn), Instituto Carlos III  Spain"},{"name":"Department de Psiquiatria Hospital Universitari Bellvitge\u2010IDIBELL  Spain"},{"name":"Department de Ci\u00e8ncies Cl\u00edniques Universitat de Barcelona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Berlanga","sequence":"additional","affiliation":[{"name":"Grup d'estudi de malalties metab\u00f2liques associades a insulin resist\u00e8ncia (GEMMAIR) Hospital Universitari de Tarragona Joan XXIII, IISPV Universitat Rovira i Virgili Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Guiu\u2010Jurado","sequence":"additional","affiliation":[{"name":"Grup d'estudi de malalties metab\u00f2liques associades a insulin resist\u00e8ncia (GEMMAIR) Hospital Universitari de Tarragona Joan XXIII, IISPV Universitat Rovira i Virgili Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Mench\u00f3n","sequence":"additional","affiliation":[{"name":"Department de Psiquiatria Hospital Universitari Bellvitge\u2010IDIBELL  Spain"},{"name":"Department de Ci\u00e8ncies Cl\u00edniques Universitat de Barcelona  Spain"},{"name":"CIBER, Salud Mental (CIBERSAM), Instituto Carlos III  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Fern\u00e1ndez\u2010Aranda","sequence":"additional","affiliation":[{"name":"CIBER, Fisiopatolog\u00eda de la Obesidad y Nutricion (CIBERObn), Instituto Carlos III  Spain"},{"name":"Department de Psiquiatria Hospital Universitari Bellvitge\u2010IDIBELL  Spain"},{"name":"Department de Ci\u00e8ncies Cl\u00edniques Universitat de Barcelona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crist\u00f3bal","family":"Richart","sequence":"additional","affiliation":[{"name":"Grup d'estudi de malalties metab\u00f2liques associades a insulin resist\u00e8ncia (GEMMAIR) Hospital Universitari de Tarragona Joan XXIII, IISPV Universitat Rovira i Virgili Tarragona Spain"},{"name":"Servei Medicina Interna, Hospital Universitari Joan XXIII Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.1047"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.1097"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-41353"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.45.26746"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0866"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.06.007"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.930600"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031260"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-42655"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1273738"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04181.x"},{"key":"e_1_2_5_13_1","first-page":"259","article-title":"Human resistin: Found in translation from mouse to man","volume":"22","author":"Schwartz DR","year":"2011","journal-title":"Trends Endocrinol Metab"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2006.06.006"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02944.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321970"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.08.043"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03325347"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/CEN.12118"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.03.001"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1279703"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.61"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-165175"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2011.05557.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.9.5559"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-1195"},{"key":"e_1_2_5_27_1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.33549\/physiolres.931575","article-title":"Serum concentrations of adipocyte fatty acid binding protein in patients with anorexia nervosa","volume":"58","author":"Haluz\u00edkov\u00e1 D","year":"2009","journal-title":"Physiol Res"},{"key":"e_1_2_5_28_1","unstructured":"First M Gibbon M Spitzer R Williams J. Users Guide for the Structured Clinical Interview for DSM IV Axis I Disorders\u2014Research Version (SCID\u2010I version 2.0). American Psychiatric Press Inc. Washington DC. 1996."},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.6.1487"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365510601158717"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01702.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1364"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2006.04.016"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1683"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2011.02.005"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-010-0551-z"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.1.8129"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.139.7.780"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-24716-3_7"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-012-0622-3"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2010.66"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feat.22166","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.22166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T06:27:37Z","timestamp":1696573657000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.22166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,23]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1002\/eat.22166"],"URL":"https:\/\/doi.org\/10.1002\/eat.22166","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,23]]}}}