{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:36:27Z","timestamp":1790710587415,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T00:00:00Z","timestamp":1375833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Cardiac damage is a major complication of anorexia nervosa (AN). The present study evaluated the prevalence of myocardial damage in patients with AN by cardiac magnetic resonance imaging (CMR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This study was cross\u2010sectional and observational. Forty consecutive female patients with a diagnosis of AN and 28 healthy female subjects were evaluated from January 2007 to 2011 at the Department of Psychiatry (University of Istanbul, Istanbul, Turkey). Following enrolment in the study, participants underwent a cardiac evaluation, a physical examination, a standard electrocardiogram (ECG), an echocardiography and a CMR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Body weight, body mass index and heart rate values were lower in patients with AN than in the control group. When compared with control groups, patients with AN showed reduced left ventricular mass with normal systolic function. Compared to control subjects, patients with AN had higher prevalence of pericardial effusion (30% in the AN group, 4% in the control group, <jats:italic>p<\/jats:italic>\u2009=\u2009.005) and mitral valve prolapses (23% in the AN group, 4% in the control group, <jats:italic>p<\/jats:italic>\u2009=\u2009.03). Myocardial fibrosis (detected as late gadolinium enhancement on CMR) was found in 23% of patients with AN. Myocardial fibrosis was not detected in any control subject (<jats:italic>p<\/jats:italic>\u2009=\u2009.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A strong association was found between myocardial fibrosis and AN. Cardiac damage of myocardial fibrosis in asymptomatic patients with AN can be found by CMR examination. \u00a9 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:862\u2013866)<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.22170","type":"journal-article","created":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T06:53:25Z","timestamp":1375858405000},"page":"862-866","source":"Crossref","is-referenced-by-count":65,"title":["Assessment of myocardial damage by cardiac MRI in patients with anorexia nervosa"],"prefix":"10.1002","volume":"46","author":[{"given":"Serap","family":"Oflaz","sequence":"first","affiliation":[{"name":"Department of Psychiatry Istanbul School of Medicine, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basak","family":"Yucel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Istanbul School of Medicine, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahrettin","family":"Oz","sequence":"additional","affiliation":[{"name":"Depatment of Cardiology Istanbul School of Medicine, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Radiology Istanbul School of Medicine, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalan","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Istanbul School of Medicine, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Yaci","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Istanbul School of Medicine, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihat","family":"Polat","sequence":"additional","affiliation":[{"name":"Depatment of Cardiology Istanbul School of Medicine, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Gurdal","sequence":"additional","affiliation":[{"name":"Depatment of Cardiology Istanbul School of Medicine, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Y.","family":"Cizgici","sequence":"additional","affiliation":[{"name":"Depatment of Cardiology Istanbul School of Medicine, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Memduh","family":"Dursun","sequence":"additional","affiliation":[{"name":"Department of Radiology Istanbul School of Medicine, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Oflaz","sequence":"additional","affiliation":[{"name":"Depatment of Cardiology Istanbul School of Medicine, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-012-0282-y"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.10222"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.72.1.69"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.71.3.287"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0070(88)90013-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-011-0227-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2143\/AC.61.1.2005139"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-005-1647-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CHI.0000046867.56865.EB"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-108X(199704)21:3<205::AID-EAT1>3.0.CO;2-O"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-1-49"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.162.4.452"},{"issue":"3","key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1161\/01.CIR.58.3.425","article-title":"Effects of self\u2010induced starvation on cardiac size and function in anorexia nervosa","volume":"58","author":"Gottdiener JS","year":"1978","journal-title":"Circulation"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0070(83)80221-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1081\/JCMR-200038581"},{"key":"e_1_2_6_17_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders: DSM IV\u2010RT","author":"American Psychiatric Association","year":"2000"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.74"},{"key":"e_1_2_6_19_1","first-page":"2012","volume-title":"Cardiovascular complications in eating disorders. Relevant topics in Eating Disorders","author":"Garrido BJ"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000028933.34260.09"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.852517"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000057"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.049"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.549659"},{"key":"e_1_2_6_25_1","first-page":"242","article-title":"Ultrastructural changes in nutritional cardiomyopathy of protein\u2010calorie malnourished rats","volume":"63","author":"Rossi MA","year":"1982","journal-title":"Br J Exp Pathol"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(79)90008-5"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00579.2009"},{"key":"e_1_2_6_28_1","first-page":"PO3","article-title":"Oxidative stress promotes ventricular fibrillation at the early stages of hypertension: Role of Ca2\n                  +\/CaM kinase\u2010II","volume":"7","author":"Sovari AA","year":"2011","journal-title":"Heart Rhythm"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.160549"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.12.1388"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000017264.66561.3D"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.033"},{"key":"e_1_2_6_33_1","first-page":"13","article-title":"Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: Slow infusion versus bolus","volume":"1","author":"Schelbert EB","year":"2011","journal-title":"J Cardiovasc Magn Reson"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.03.019"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feat.22170","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.22170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T06:28:30Z","timestamp":1696573710000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.22170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,7]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1002\/eat.22170"],"URL":"https:\/\/doi.org\/10.1002\/eat.22170","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,7]]}}}