{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:24:23Z","timestamp":1792099463001,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,9,14]],"date-time":"2013-09-14T00:00:00Z","timestamp":1379116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The evidence for pharmacological treatment of severe, longstanding anorexia nervosa (AN) is sparse and the few controlled pharmacologic studies have focused on a narrow range of drugs. The aim of the present study was to investigate the effects of treatment with a synthetic cannabinoid agonist on body weight and eating disorder\u2010related psychopathological personality traits in women with severe, enduring AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This add\u2010on, prospective, randomized, double blind, controlled crossover study was conducted between 2008 and 2011 at a specialized care center for eating disorders. Twenty\u2010five women over 18 years with AN of at least 5 years duration were randomized to treatment with either dronabinol\u2010placebo or placebo\u2010dronabinol. In addition to the standardized baseline therapeutic regime, the participants received dronabinol, 2.5 mg twice daily for 4 weeks and matching placebo for 4 weeks, separated by a 4\u2010week wash\u2010out period. Primary outcome was the mean change in body weight. Secondary outcome was score changes on the Eating Disorder Inventory\u20102 (EDI\u20102). Data were analyzed for the 24 patients who completed the trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During dronabinol treatment, participants gained 0.73 kg (<jats:italic>t<\/jats:italic>\u2009=\u20092.86, df\u2009=\u200922, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) above placebo without significant psychotropic adverse events. Dronabinol significantly predicted weight gain in a multiple linear regression including EDI\u20102 body dissatisfaction score and leptin. EDI\u20102 subscale scores showed no significant changes over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Dronabinol therapy was well tolerated. During four weeks of exposure it induced a small but significant weight gain in the absence of severe adverse events. \u00a9 2013 Wiley Periodicals, Inc. 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