{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:48:42Z","timestamp":1758815322483},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The female preponderance and onset around puberty in the majority of eating disorders (EDs) suggest that sex hormones, like estrogens, may be involved in the onset of these disorders. An eight\u2010SNP haplotype at the estrogen receptor I (ESR1) gene was found to be associated with anorexia nervosa (AN) (Versini et al., Neuropsychopharmacology, 35, 1818\u20131825, 2010) and three SNPs from this haplotype (rs726281, rs2295193, and rs3798577) were associated with AN and\/or EDs. Our objective was to replicate these findings in an independent cohort of 520 patients with an eating disorder, of whom 244 had AN (142 restricting type) from the GenED study and 2,810 random women from the Netherlands Twin Registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The frequencies of the eight\u2010SNP haplotype and three <jats:italic>ESR1<\/jats:italic> SNPs were compared between patients with an eating disorder, with AN (restricting type), with bulimia nervosa (BN), and the control women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neither the haplotype nor the three <jats:italic>ESR1<\/jats:italic> SNPs were associated with EDs, BN, AN, or restricting type AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Despite sufficient statistical power, the associations reported by Versini et al. (Neuropsychopharmacology, 35, 1818\u20131825, 2010) were not replicated. \u00a9 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:211\u2013214)<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.22228","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T04:14:02Z","timestamp":1385525642000},"page":"211-214","source":"Crossref","is-referenced-by-count":4,"title":["Association study of the estrogen receptor I gene (<i>ESR1<\/i>) in anorexia nervosa and eating disorders: No replication found"],"prefix":"10.1002","volume":"47","author":[{"given":"Margarita C.T.","family":"Slof\u2010Op 't Landt","sequence":"first","affiliation":[{"name":"Center for Eating Disorders Ursula Leidschendam The Netherlands"},{"name":"Leiden University Medical Centre Molecular Epidemiology Section (Department of Medical Statistics) Leiden The Netherlands"},{"name":"Department of Biological Psychology VU University Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric F.","family":"van Furth","sequence":"additional","affiliation":[{"name":"Center for Eating Disorders Ursula Leidschendam The Netherlands"},{"name":"Leiden University Medical Centre Department of Psychiatry Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Meulenbelt","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre Molecular Epidemiology Section (Department of Medical Statistics) Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meike","family":"Bartels","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology VU University Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jouke Jan","family":"Hottenga","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology VU University Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Eline","family":"Slagboom","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre Molecular Epidemiology Section (Department of Medical Statistics) Leiden The Netherlands"},{"name":"Netherlands Consortium for Healthy Ageing Leiden University Medical Center  The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorret I.","family":"Boomsma","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology VU University Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.040"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199407000-00034"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20316"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.4.8"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.04.014"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2009.06.010"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.49"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1210\/jcem.83.12.5471","article-title":"Systematic mutation screening of the estrogen receptor beta gene in probands of different weight extremes: Identification of several genetic variants","volume":"83","author":"Rosenkranz K","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000929"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001402"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2010.00660.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2012.118"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2012.140"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2796"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2088"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291709992236"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feat.22228","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.22228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T22:37:29Z","timestamp":1696545449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.22228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,26]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1002\/eat.22228"],"URL":"https:\/\/doi.org\/10.1002\/eat.22228","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,26]]}}}