{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:14:16Z","timestamp":1759032856700},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T00:00:00Z","timestamp":1387152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Some patients with symptoms of binge eating and purging are successfully treated with specific serotonin reuptake inhibitors (SSRIs), but others experience only partial or no benefit. Significant affect dysregulation and poor impulse control may be characteristics that limit responsiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We report on the treatment of five patients with bulimia nervosa (BN), anorexia nervosa\u2014binge\/purge type (AN\u2010B\/P) or eating disorder not otherwise specified (EDNOS), using the anticonvulsant lamotrigine after inadequate response to SSRIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following addition of lamotrigine to an antidepressant in four cases, and switch from an antidepressant to lamotrigine in one case, patients experienced substantial improvement in mood reactivity and instability, impulsive drives and behaviors, and eating\u2010disordered symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These findings raise the possibility that lamotrigine, either as monotherapy or as an augmenting agent to antidepressants, may be useful in patients who binge eat and purge, and have significant affect dysregulation with poor impulse control. \u00a9 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:329\u2013334)<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.22234","type":"journal-article","created":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T05:04:26Z","timestamp":1387256666000},"page":"329-334","source":"Crossref","is-referenced-by-count":17,"title":["Lamotrigine use in patients with binge eating and purging, significant affect dysregulation, and poor impulse control"],"prefix":"10.1002","volume":"47","author":[{"given":"Mary Ellen","family":"Trunko","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of California San Diego San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry A.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California San Diego San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrica","family":"Marzola","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California San Diego San Diego California"},{"name":"Department of Neuroscience Section of Psychiatry, University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela S.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California San Diego San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter H.","family":"Kaye","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California San Diego San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22104"},{"key":"e_1_2_6_3_1","unstructured":"American Psychiatric Association.Practice Guideline for the Treatment of Patients with Eating Disorders 3rd ed.American Psychiatric Association Washington (DC) 2006."},{"issue":"4","key":"e_1_2_6_4_1","first-page":"003391","article-title":"Antidepressants versus placebo for people with bulimia nervosa","author":"Bacaltchuk J","year":"2003","journal-title":"Coch Database Syst Rev"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(199305)13:4<349::AID-EAT2260130403>3.0.CO;2-C"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11126-012-9208-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n1208"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n1109"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20202"},{"key":"e_1_2_6_10_1","first-page":"59","article-title":"Comparative effectiveness of mood stabilizers in the complex therapy of bulimia nervosa","volume":"110","author":"Marilov V","year":"2010","journal-title":"Zh Nevrol Psikhiatr Im S S Korsakova"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e328329c7b5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.09.002"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2004.11.008"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.6.11.1609"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e3182055c07"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-013-0088-z"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000219927.49799.c0"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2006.07.005"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n1110"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161211796150828"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.01.003"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feat.22234","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.22234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T22:39:58Z","timestamp":1696545598000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.22234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,16]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1002\/eat.22234"],"URL":"https:\/\/doi.org\/10.1002\/eat.22234","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,16]]}}}