{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T13:57:14Z","timestamp":1764079034984},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T00:00:00Z","timestamp":1395014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"German Federal Ministry of Education and Research","award":["01GV1002"],"award-info":[{"award-number":["01GV1002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate direct and indirect costs of anorexia nervosa (AN), and to identify cost determinants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a subsample (<jats:italic>n<\/jats:italic>\u2009=\u2009225) of the ANTOP trial (Anorexia Nervosa Treatment of OutPatients) health care utilization and productivity losses were assessed at baseline for the previous 3 months and monetarily valued. Included were females aged 18 years and older diagnosed with AN or subsyndromal AN, and a body mass index (BMI) between 15 and 18.5 kg\/m<jats:sup>2<\/jats:sup>. To account for missing data multiple imputation was employed. Cost determinants were derived from generalized linear models with gamma distribution and log link function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean 3\u2010months costs per patient amounted to \u20ac5,866 (SE\u2009=\u2009\u20ac576). The largest share of costs (\u20ac3,374) resulted from hospitalizations. Determinants of direct costs were analyzed separately for those with hospitalizations for AN, and those without. In the group only treated as outpatients, participants with binge\/purge subtype, and those diseased for more than 6 years had higher costs. Moreover, costs were increased in patients with a comorbid mental disorder. In the group with hospitalizations, direct costs increased with BMI. BMI was measured at the end of the observation period, indicating that longer duration of treatment yielded higher weight gain. Indirect costs were not significantly associated with any disease\u2010related characteristic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Costs resulting from health care utilization and productivity loss are substantial, although the sample studied had not received sufficient treatment. Future research should analyze the development of costs over time. \u00a9 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2015; 48:139\u2013146)<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.22274","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T04:59:57Z","timestamp":1395032397000},"page":"139-146","source":"Crossref","is-referenced-by-count":50,"title":["Determinants of direct and indirect costs in anorexia nervosa"],"prefix":"10.1002","volume":"48","author":[{"given":"Nina","family":"Stuhldreher","sequence":"first","affiliation":[{"name":"Department of Health Economics and Health Services Research Hamburg Center for Health Economics (HCHE) University Medical Center Hamburg\u2010Eppendorf  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beate","family":"Wild","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine and Psychosomatics Heidelberg University Hospital  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Helmut","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Department of Health Economics and Health Services Research Hamburg Center for Health Economics (HCHE) University Medical Center Hamburg\u2010Eppendorf  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Konnopka","sequence":"additional","affiliation":[{"name":"Department of Health Economics and Health Services Research Hamburg Center for Health Economics (HCHE) University Medical Center Hamburg\u2010Eppendorf  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Zipfel","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy University Hospital T\u00fcbingen  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Herzog","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine and Psychosomatics Heidelberg University Hospital  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-012-0282-y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00115-010-3231-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199401000-00003"},{"key":"e_1_2_7_5_1","volume-title":"The Course of Eating Disorders. Long\u2010Term Follow\u2010Up Studies of Anorexia and Bulimia Nervosa","author":"Herzog W","year":"1992"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05363-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170100407X"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmh.13.1.1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000322360"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20977"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20903"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61746-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.177.39.s28"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2011.01741.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.05.008"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00285.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2018"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta3060","article-title":"Assessing the costs of healthcare technologies in clinical trials","volume":"3","author":"Johnston K","year":"1999","journal-title":"Health Technol Assessment"},{"key":"e_1_2_7_19_1","volume-title":"Eating Disorder inventory\u20102. Deutsche Version","author":"Paul T","year":"2004"},{"key":"e_1_2_7_20_1","volume-title":"Strukturiertes Klinisches Interview f\u00fcr DSM\u2010IV (SKID)","author":"Wittchen HU","year":"1997"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-858698"},{"key":"e_1_2_7_22_1","article-title":"Rote Liste 2008. Arzneimittelverzeichnis f\u00fcr Deutschland. Frankfurt am Main","author":"Rote Liste Service GmbH","year":"2008","journal-title":"Rote Liste Service GmbH"},{"key":"e_1_2_7_23_1","volume-title":"Pflegestatistik 2007","author":"Statistisches Bundesamt","year":"2008"},{"key":"e_1_2_7_24_1","volume-title":"Verdienste und Arbeitskosten","author":"Statistisches Bundesamt","year":"2009"},{"key":"e_1_2_7_25_1","unstructured":"AOK Bundesverband.Krankenhausbezogene Zusammenstellung der vereinbarten Basisfallwerte.2008."},{"key":"e_1_2_7_26_1","unstructured":"InEK.Fallpauschalenkatalog 2008.2008a."},{"key":"e_1_2_7_27_1","unstructured":"InEK.Datenbereitstellung gem. \u00a7 21 KHEntgG zum Zweck der Begleitforschung gem. \u00a7 17b Abs. 8 KHG Datenjahr 2008.2008b."},{"key":"e_1_2_7_28_1","volume-title":"Bestandsaufnahme zur Krankenhausplanung und Investitionsfinanzierung in den Bundesl\u00e4ndern","author":"Deutsche Krankenhausgesellschaft","year":"2009"},{"key":"e_1_2_7_29_1","volume-title":"Kostennachweis der Krankenh\u00e4user 2008","author":"Statistisches Bundesamt","year":"2009"},{"key":"e_1_2_7_30_1","volume-title":"Grunddaten der Krankenh\u00e4user 2008","author":"Statistisches Bundesamt","year":"2009"},{"key":"e_1_2_7_31_1","volume-title":"Volkswirtschaftliche Gesamtrechnungen 2009","author":"Statistisches Bundesamt","year":"2010"},{"key":"e_1_2_7_32_1","volume-title":"Verbraucherpreisindizes f\u00fcr Deutschland","author":"Statistisches Bundesamt","year":"2010"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0b013e3181f475cc"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000126683.75201.c5"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327906mbr3304_5"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11121-007-0070-9"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhealeco.2004.09.011"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxh020"},{"key":"e_1_2_7_39_1","first-page":"1","article-title":"A multivariate technique for multiply imputing missing values using a sequence of regression models","volume":"27","author":"Raghunathan TE","year":"2001","journal-title":"SurveyMethodology"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v045.i03"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-002-0137-2"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-108X(200005)27:4<381::AID-EAT2>3.0.CO;2-U"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20651"},{"key":"e_1_2_7_44_1","volume-title":"Beitr\u00e4ge zur Gesundheitsberichterstattung des Bundes: Gesundheit und Krankheit im Alter","author":"N\u00f6then M","year":"2009"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1090234"},{"key":"e_1_2_7_46_1","volume-title":"Krankheitsbedingte Fehlzeiten aufgrund psychischer Erkrankungen \u2010 Eine Analyse der AOK\u2010Arbeitsunf\u00e4higkeitdaten des Jahres 2008","author":"Heyde K","year":"2010"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feat.22274","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.22274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T01:53:57Z","timestamp":1696643637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.22274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,17]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1002\/eat.22274"],"URL":"https:\/\/doi.org\/10.1002\/eat.22274","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,17]]}}}