{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:01:27Z","timestamp":1789650087940,"version":"4.0.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T00:00:00Z","timestamp":1408665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["SP037129"],"award-info":[{"award-number":["SP037129"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH079979"],"award-info":[{"award-number":["MH079979"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005197","name":"Hilda and Preston Davis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Weak central coherence\u2014a tendency to process details at the expense of the gestalt\u2014has been observed among adults with bulimia nervosa (BN) and is a potential candidate endophenotype for eating disorders (EDs). However, as BN behaviors typically onset during adolescence it is important to assess central coherence in this younger age group to determine whether the findings in adults are likely a result of BN or present earlier in the evolution of the disorder. This study examines whether the detail\u2010oriented and fragmented cognitive inefficiency observed among adults with BN is observable among adolescents with shorter illness duration, relative to healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>The Rey\u2010Osterrieth Complex Figure Test (RCFT) was administered to a total of 47 adolescents with DSM5 BN, 42 with purging disorder (PD), and 25 healthy controls (HC). Performance on this measure was compared across the three groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Those with BN and PD demonstrated significantly worse accuracy scores compared to controls in the copy and delayed recall condition with a moderate effect size. These findings were exacerbated when symptoms of BN increased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Poorer accuracy scores reflect a fragmented and piecemeal strategy that interferes with visual\u2010spatial integration in BN spectrum disorders. This cognitive inefficiency likely contributes to broad difficulties in executive functioning in this population especially in the context of worsening bulimic symptoms. The findings of this study support the hypothesis that poor global integration may constitute a cognitive endophenotype for BN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.22340","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T02:43:10Z","timestamp":1408675390000},"page":"487-493","source":"Crossref","is-referenced-by-count":20,"title":["Central coherence in adolescents with bulimia nervosa spectrum eating disorders"],"prefix":"10.1002","volume":"48","author":[{"given":"Alison M.","family":"Darcy","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Child and Adolescent Psychiatry, Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen Kara","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Child and Adolescent Psychiatry, Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Manasse","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Child and Adolescent Psychiatry, Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandini","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Child and Adolescent Psychiatry, Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Klabunde","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Center for Interdisciplinary Brain Sciences Research Stanford University School of Medicine Stanford 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Psychiatry and Behavioral Neuroscience The University of Chicago Medical Center Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Le Grange","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience The University of Chicago Medical Center Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Lock","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Child and Adolescent Psychiatry, Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,22]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Diagnostic and Statistical Manual of Mental 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