{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:38:37Z","timestamp":1790264317344,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T00:00:00Z","timestamp":1414972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["RP-PG-0606-1043"],"award-info":[{"award-number":["RP-PG-0606-1043"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to explore the neuro\u2010 and social\u2010cognitive profile of a consecutive series of adult outpatients with anorexia nervosa (AN) when compared with widely available age and gender matched historical control data. The relationship between performance profiles, clinical characteristics, service utilization, and treatment adherence was also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Consecutively recruited outpatients with a broad diagnosis of AN (restricting subtype AN\u2010R: <jats:italic>n<\/jats:italic>\u2009=\u200944, binge\u2010purge subtype AN\u2010BP: <jats:italic>n<\/jats:italic>\u2009=\u200933 or Eating Disorder Not Otherwise Specified\u2010AN subtype EDNOS\u2010AN: <jats:italic>n<\/jats:italic>\u2009=\u200923) completed a comprehensive set of neurocognitive (set\u2010shifting, central coherence) and social\u2010cognitive measures (Emotional Theory of Mind). Data were subjected to hierarchical cluster analysis and a discriminant function analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three separate, meaningful clusters emerged. Cluster 1 (<jats:italic>n<\/jats:italic>\u2009=\u200945) showed overall average to high average neuro\u2010 and social\u2010 cognitive performance, Cluster 2 (<jats:italic>n<\/jats:italic>\u2009=\u200938) showed mixed performance characterized by distinct strengths and weaknesses, and Cluster 3 (<jats:italic>n<\/jats:italic>\u2009=\u200917) showed poor overall performance (Autism Spectrum disorder (ASD) like cluster). The three clusters did not differ in terms of eating disorder symptoms, comorbid features or service utilization and treatment adherence. A discriminant function analysis confirmed that the clusters were best characterized by performance in perseveration and set\u2010shifting measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The findings suggest that considerable neuro\u2010 and social\u2010cognitive heterogeneity exists in patients with AN, with a subset showing ASD\u2010like features. The value of this method of profiling in predicting longer term patient outcomes and in guiding development of etiologically targeted treatments remains to be seen. \u00a9 2014 Wiley Periodicals, Inc. 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