{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:21:19Z","timestamp":1790781679711,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,29]],"date-time":"2014-11-29T00:00:00Z","timestamp":1417219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Anorexia nervosa (AN) is a complex disorder involving severe psychological manifestations and multiple organ damage, including liver dysfunction. The primary aim of this study consisted in assessing plasma levels of vitamin B<jats:sub>12<\/jats:sub> and folates with respect to liver function enzymes considering the liver\u2010storage properties of this vitamin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We recruited 70 restrictive type AN adolescents and the severity of psychopathological traits was assessed using EDI\u20103 scale. Plasma levels of vitamin B<jats:sub>12<\/jats:sub>, folates, transaminases (AST, ALT), gamma\u2010glutamyl <jats:italic>transpeptidase (GGT)<\/jats:italic>, alkaline phosphatase (ALP) and cholinesterase (CHE) were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About 38.5% of patients displayed vitamin B<jats:sub>12<\/jats:sub> values (H\u2010B12) above the upper range of normal reference; 4.3% of patients had increased values of folates; 20 and 11.4% of patients displayed ALT and AST values above reference limits; none had GGT values above normal range. Albeit low CHE and ALP values were found in 55 and 20% of patients, respectively, a linear correlation with both transaminases was present only for vitamin B<jats:sub>12<\/jats:sub> and folates; furthermore, H\u2010B12 patients had both higher AST and ALT values. EDI\u2010 3 subscores significantly correlated with vitamin B<jats:sub>12<\/jats:sub> and folates plasma values and H\u2010B12 patients displayed EDI\u20103 higher values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These data suggest that plasma levels of vitamin B<jats:sub>12<\/jats:sub> might be an early marker of liver dysfunction, possibly also related to more severe psychopathological aspects. The identification of patients with higher fasting plasma vitamin B<jats:sub>12<\/jats:sub> levels could therefore lead to earlier and more careful refeeding interventions. Further studies will clarify the potential role of this vitamin in AN clinical practice. \u00a9 2014 Wiley Periodicals, Inc. 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