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We investigated the extent to which AN is associated with a distinct methylation profile compared to that seen in normal\u2010eater women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Genome\u2010wide methylation profiles, obtained using DNA from whole blood, were determined in 29 women currently ill with AN (10 with AN\u2010restrictive type, 19 with AN\u2010binge\/purge type) and 15 normal\u2010weight, normal\u2010eater control women, using 450 K Illumina bead arrays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regardless of type, AN patients showed higher and less\u2010variable global methylation patterns than controls. False Discovery Rate corrected comparisons identified 14 probes that were hypermethylated in women with AN relative to levels obtained in normal\u2010eater controls, representing genes thought to be associated with histone acetylation, RNA modification, cholesterol storage and lipid transport, and dopamine and glutamate signaling. Age of onset was significantly associated with differential methylation in gene pathways involved in development of the brain and spinal cord, while chronicity of illness was significantly linked to differential methylation in pathways involved with synaptogenesis, neurocognitive deficits, anxiety, altered social functioning, and bowel, kidney, liver and immune function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Although pre\u2010existing differences cannot be ruled out, our findings are consistent with the idea of secondary alterations in methylation at genomic regions pertaining to social\u2010emotional impairments and physical sequelae that are commonly seen in AN patients. Further investigation is needed to establish the clinical relevance of the affected genes in AN, and, importantly, reversibility of effects observed with nutritional rehabilitation and treatment. \u00a9 2015 Wiley Periodicals, Inc. 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