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The review was completed in accordance with PRISMA standards.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 123 articles were retained, including one randomized control trial. The majority of included studies were case reports and case series. Controlled studies demonstrated that patients with AN were more likely to have delays in gastric motility, gastric emptying and intestinal transit than comparator groups although results were not uniform across all studies. Published reports suggest that complications can occur at any segment of the GI tract. These issues may derive as a consequence of severe malnourishment, from eating disorder related symptoms such as self\u2010induced purging or from the refeeding process itself. Multiple studies noted that patients with AN report high rates of GI symptoms although in the few cases where medical testing was undertaken, correlations between self\u2010reported symptoms and measurable pathology were not demonstrated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>GI complications may occur throughout the entire GI tract in patients with AN. It is recommended that clinicians use careful judgment when pursuing targeted investigation or introducing symptom specific treatments in response to GI complaints. Evidence suggests that most GI complications resolve with refeeding and cessation of ED symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.22462","type":"journal-article","created":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T02:13:42Z","timestamp":1443233622000},"page":"216-237","source":"Crossref","is-referenced-by-count":151,"title":["Gastrointestinal complications associated with anorexia nervosa: A systematic review"],"prefix":"10.1002","volume":"49","author":[{"given":"Mark L.","family":"Norris","sequence":"first","affiliation":[{"name":"Department of Pediatrics Children's Hospital of Eastern Ontario, University of Ottawa Ottawa Ontario Canada"},{"name":"Children's Hospital of Eastern Ontario Research Institute Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital of Eastern Ontario, University of Ottawa Ottawa Ontario Canada"},{"name":"Children's Hospital of Eastern Ontario Research Institute Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanna","family":"Isserlin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Children's Hospital of Eastern Ontario, University of Ottawa Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital of Eastern Ontario, University of Ottawa Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Feder","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital of Eastern Ontario, University of Ottawa Ottawa Ontario Canada"},{"name":"Children's Hospital of Eastern Ontario Research Institute Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Sampson","sequence":"additional","affiliation":[{"name":"Library and Media Services Children's Hospital of Eastern Ontario Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20118"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850171819"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_11_5_1","unstructured":"BalkEM ChungM HadarN PatelK YuWW TrikalinosTAet al. 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