{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:07:35Z","timestamp":1792084055083,"version":"4.4.0"},"reference-count":77,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Glassman Endowment"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Anorexia nervosa portends the highest mortality among psychiatric diseases, despite primarily being a disease of adolescents and younger adults. Although some of this mortality risk is attributable to suicide, many deaths are likely cardiovascular in etiology. Recent studies suggest that adverse myocardial structural changes occur in this condition, which could underlie the increased mortality. Given limited prevalence of severe anorexia there is a paucity of clinical and autopsy data to discern an exact cause of death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Given this background we conducted a systematic review of the medical literature to provide a contemporary summary of the pathobiologic sequelae of severe anorexia nervosa on the cardiovascular system. We sought to elucidate the impact of anorexia nervosa in four cardiovascular domains: structural, repolarization\/conduction, hemodynamic, and peripheral vascular.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A number of cardiac abnormalities associated with anorexia nervosa have been described in the literature, including pericardial and valvular pathology, changes in left ventricular mass and function, conduction abnormalities, bradycardia, hypotension, and dysregulation in peripheral vascular contractility. Despite the prevalent theory that malignant arrhythmias are implicated as a cause of sudden death in this disorder, data to support this causal relationship are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>It is reasonable to obtain routine electrocardiography and measurements of orthostatic vital signs in patients presenting with anorexia nervosa. Echocardiography is generally not indicated unless prompted by clinical signs of disease. Admission to an inpatient unit with telemetry monitoring is recommended for patients with severe sinus bradycardia or junction rhythm, marked prolongation of the corrected QT interval, or syncope.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.22481","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T06:44:52Z","timestamp":1451371492000},"page":"238-248","source":"Crossref","is-referenced-by-count":228,"title":["Cardiovascular complications of anorexia nervosa: A systematic review"],"prefix":"10.1002","volume":"49","author":[{"given":"Katherine V.","family":"Sachs","sequence":"first","affiliation":[{"name":"Department of Medicine Denver Health Medical Center Denver Colorado"},{"name":"University of Colorado School of Medicine Denver Aurora"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Harnke","sequence":"additional","affiliation":[{"name":"Health Sciences Library University of Colorado Anschutz Medical Campus Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip S.","family":"Mehler","sequence":"additional","affiliation":[{"name":"Department of Medicine Denver Health Medical Center Denver Colorado"},{"name":"University of Colorado School of Medicine Denver Aurora"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mori J.","family":"Krantz","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine Denver Aurora"},{"name":"Division of Cardiology Denver Health Medical Center Denver Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,29]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10640261003719484"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.10146"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-011-0227-8"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.5603\/CJ.2012.0117"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20307"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20841"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(94)90270-4"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-25-11-1520"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.44.510.327"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20041151"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-108X(199809)24:2<217::AID-EAT11>3.0.CO;2-W"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.10190"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2014.07.621"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-1-49"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.71.3.287"},{"key":"e_1_2_4_17_1","first-page":"137","article-title":"Predictors of diminished corrected left ventricular mass index in female anorexic adolescents","volume":"46","author":"Docx M","year":"2014","journal-title":"Anaesthesiol Intensive Ther"},{"key":"e_1_2_4_18_1","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1001\/archinte.1986.00360200083014","article-title":"Mitral valve prolapse in patients with anorexia nervosa and bulimia","volume":"146","author":"Johnson GL","year":"1986","journal-title":"Arch Intern Med"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.5402\/2011\/171460"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0070(88)90013-7"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.03.006"},{"key":"e_1_2_4_22_1","first-page":"B41","article-title":"Myocardial strain and torsion quantification in patients with restrictive\u2010type anorexia nervosa","volume":"27","author":"Almeida\u2010Jones ME","year":"2014","journal-title":"J Am Soc Echocardiogr"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.crd.0000216745.96062.7c"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.141.5.702"},{"key":"e_1_2_4_25_1","first-page":"453","article-title":"Myopathy due to ipecac syrup poisoning in a patient with anorexia nervosa","volume":"125","author":"Brotman MC","year":"1981","journal-title":"Can Med Assoc J"},{"key":"e_1_2_4_26_1","first-page":"36","article-title":"Heart transplantation in a young patient with anorexia nervosa\u2014A perspective? A case report","volume":"26","author":"Tigges\u2010Limmer K","year":"2013","journal-title":"Transplant Int"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.10.068"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CHI.0000046867.56865.EB"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.019"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.3276"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2003.tb00549.x"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22170"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP4PLFF1TTKENT"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-108X(199704)21:3<205::AID-EAT1>3.0.CO;2-O"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(85)90061-5"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.72.1.69"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1999.tb01101.x"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(94)90266-6"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-8932(03)76937-1"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-005-1647-6"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.5.561"},{"key":"e_1_2_4_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/15622970701230963"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2011.08.003"},{"key":"e_1_2_4_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20082"},{"key":"e_1_2_4_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.09.055"},{"key":"e_1_2_4_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.01.041"},{"key":"e_1_2_4_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192704"},{"key":"e_1_2_4_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.5.1557"},{"key":"e_1_2_4_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2006.00379.x"},{"key":"e_1_2_4_50_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.122726"},{"key":"e_1_2_4_51_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335481"},{"key":"e_1_2_4_52_1","first-page":"486","article-title":"Management of sinus node dysfunction with junctional escape rhythm in a case of anorexia nervosa","volume":"38","author":"Kossaify A.","year":"2010","journal-title":"Turk Kardiyoloji Dernegi Ars"},{"key":"e_1_2_4_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20647"},{"key":"e_1_2_4_54_1","first-page":"177","article-title":"Sinus bradycardia in anorexia nervosa\u2014A case report","volume":"45","author":"Habil MH","year":"1990","journal-title":"Med J Malaysia"},{"key":"e_1_2_4_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e3182447a56"},{"key":"e_1_2_4_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.2.308"},{"key":"e_1_2_4_57_1","first-page":"410","article-title":"Effects of neuroendocrine changes on results of ambulatory blood pressure monitoring (ABPM) in adolescent girls with anorexia nervosa","volume":"28","author":"Oswiecimska J","year":"2007","journal-title":"Neuroendocrinol Lett"},{"key":"e_1_2_4_58_1","first-page":"83","article-title":"The significance of bradycardia in anorexia nervosa","volume":"22","author":"Yahalom M","year":"2013","journal-title":"Int"},{"key":"e_1_2_4_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-4-10"},{"key":"e_1_2_4_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-139X(02)00533-5"},{"key":"e_1_2_4_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.10262"},{"key":"e_1_2_4_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.08.013"},{"key":"e_1_2_4_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060636"},{"key":"e_1_2_4_64_1","first-page":"354","article-title":"Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology","volume":"17","author":"Heart rate variability.","year":"1996","journal-title":"Eur Heart J"},{"key":"e_1_2_4_65_1","first-page":"814","article-title":"Electronic evaluation of the fetal heart rate. VIII. Patterns preceding fetal death, further observations","volume":"87","author":"Hon EH","year":"1963","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_4_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)90795-8"},{"key":"e_1_2_4_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)90601-1"},{"key":"e_1_2_4_68_1","first-page":"87","article-title":"Heart rate variability as a measure of cardiac autonomic function in anorexia nervosa: A review of the literature","volume":"19","author":"Mazurak N","year":"2011","journal-title":"Eur"},{"key":"e_1_2_4_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.07.103"},{"key":"e_1_2_4_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000227876.19909.48"},{"key":"e_1_2_4_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13030-015-0032-6"},{"key":"e_1_2_4_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1978.tb16307.x"},{"key":"e_1_2_4_73_1","first-page":"634","article-title":"Flow\u2010mediated vasodilatation in the patients with anorexia nervosa","volume":"114","author":"Palova S","year":"2013","journal-title":"Bratisl Lek Listy"},{"key":"e_1_2_4_74_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X11398519"},{"key":"e_1_2_4_75_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.67.783.33"},{"key":"e_1_2_4_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20418"},{"key":"e_1_2_4_77_1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1177\/014107689008300807","article-title":"Anorexia nervosa associated with acromegaloid features, onset of acrocyanosis and Raynaud's phenomenon and worsening of chilblains","volume":"83","author":"Rustin MH","year":"1990","journal-title":"J R Soc Med"},{"key":"e_1_2_4_78_1","first-page":"1850","article-title":"Digital necrosis in a patient with anorexia nervosa. Association of vasculopathy and radial artery injury","volume":"29","author":"Launay D","year":"2000","journal-title":"Presse Med"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feat.22481","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.22481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T06:18:18Z","timestamp":1695622698000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.22481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,29]]},"references-count":77,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1002\/eat.22481"],"URL":"https:\/\/doi.org\/10.1002\/eat.22481","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,29]]}}}