{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:49:03Z","timestamp":1781758143081,"version":"3.54.5"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T00:00:00Z","timestamp":1487808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK092608"],"award-info":[{"award-number":["DK092608"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Because binge eating and emotional eating vary through the menstrual cycle in human females, we investigated cyclic changes in binge\u2010like eating in female rats and their control by estrogens. Binge\u2010like eating was elicited by three cycles of 4 days of food restriction and 4 days of free feeding followed by a single frustrative nonreward\u2010stress episode (15 min visual and olfactory exposure to a familiar palatable food) immediately before presentation of the palatable food. Intact rats showed binge\u2010like eating during the diestrous and proestrous phases of the ovarian cycle, but not during the estrous (periovulatory) phase. Ovariectomized (OVX) rats not treated with estradiol (E2) displayed binge\u2010like eating, whereas E2\u2010treated OVX rats did not. The procedure did not increase signs of anxiety in an open\u2010field test. OVX rats not treated with E2 that were subjected to food restriction and sacrificed immediately after frustrative nonreward had increased numbers of cells expressing phosphorylated extracellular signal\u2010regulated kinases (ERK) in the central nucleus of the amygdala (CeA), paraventricular nucleus of hypothalamus (PVN), and dorsal and ventral bed nuclei of the stria terminalis (BNST) compared with nonrestricted or E2\u2010treated rats. These data suggest that this female rat model is appropriate for mechanistic studies of some aspects of menstrual\u2010cycle effects on emotional and binge eating in human females, that anxiety is not a sufficient cause of binge\u2010like eating, and that the PVN, CeA, and BNST may contribute to information processing underlying binge\u2010like eating.<\/jats:p>","DOI":"10.1002\/eat.22687","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T11:25:59Z","timestamp":1487849159000},"page":"624-635","source":"Crossref","is-referenced-by-count":66,"title":["Estrogenic suppression of binge\u2010like eating elicited by cyclic food restriction and frustrative\u2010nonreward stress in female rats"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8044-1206","authenticated-orcid":false,"given":"Maria Vittoria","family":"Micioni Di Bonaventura","sequence":"first","affiliation":[{"name":"School of Pharmacy Pharmacology Unit, University of Camerino 62032 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Lutz","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Physiology and Center for Integrative Human Physiology, University of Zurich 8057 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Sapienza University of Rome 00185 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Pucci","sequence":"additional","affiliation":[{"name":"Faculty of Bioscience and Technology for Food, Agriculture and Environment University of Teramo 64100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nori","family":"Geary","sequence":"additional","affiliation":[{"name":"Department of Psychiatry (Retired) Weill Medical College of Cornell University New York 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2599-6855","authenticated-orcid":false,"given":"Lori","family":"Asarian","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Physiology and Center for Integrative Human Physiology, University of Zurich 8057 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6180-828X","authenticated-orcid":false,"given":"Carlo","family":"Cifani","sequence":"additional","affiliation":[{"name":"School of Pharmacy Pharmacology Unit, University of Camerino 62032 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.2002.1835"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00446.2012"},{"key":"e_1_2_8_5_1","volume-title":"Methods of Behavior Analysis in Neuroscience","author":"Bailey K. R.","year":"2009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1142"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-013-9259-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74726"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-104-2_3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2010.09.006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1442-y"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20349"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.04.041"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(98)00201-7"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301430"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-016-0701-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.46"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2009.10.004"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2000.00527.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(200012)28:4<436::AID-EAT12>3.0.CO;2-P"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.281.3.R738"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(00)00278-X"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291706008956"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00102.2006"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22016"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012515400-0\/50048-8"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1440659"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2010.04.011"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.040"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0029524"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/2167702614521794"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22139"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.07.041"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.02.006"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20221"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2009.03.005"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1854-14.2014"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e3283566a60"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3013-0"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/956137"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852915000656"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.48"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20044"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12303"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1101894108"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.84.6.1098"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90438-3"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0020909"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.08.016"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.22"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00158-X"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61748-7"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171500104X"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(200012)28:4<460::AID-EAT16>3.0.CO;2-A"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(198602)5:2<295::AID-EAT2260050209>3.0.CO;2-T"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0076186"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-17-05425.1996"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2008.07.021"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.07.017"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012515400-0\/50050-6"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feat.22687","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.22687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T11:47:33Z","timestamp":1696592853000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.22687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,23]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1002\/eat.22687"],"URL":"https:\/\/doi.org\/10.1002\/eat.22687","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727338329.793556482","asserted-by":"object"}]},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,23]]}}}