{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:59:32Z","timestamp":1792612772643,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T00:00:00Z","timestamp":1496793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the study was to investigate a potential role for vitamin D status on bone mineral density (BMD) during weight gain in patients with anorexia nervosa (AN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Spine and hip BMD assessed by dual\u2010energy X\u2010ray absorptiometry (DXA), serum vitamin D (25\u2010OH\u2010D), <jats:italic>N<\/jats:italic>\u2010propeptide of type I collagen (P1NP), C\u2010terminal telopeptide of type I collagen (CTX), and intact parathyroid hormone (PTH) were measured before and after a 20\u2010week intensive weight\u2010restoration program in ninety\u2010one female patients with AN and secondary amenorrhoea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010one consecutive female patients (age 13\u201345 years; weight 39.4\u2009\u00b1\u20095.6 kg, body mass index [BMI] 15.1\u2009\u00b1\u20091.6 kg\u00a0m<jats:sup>\u22122<\/jats:sup>) were included in the study. Although weight and BMI significantly increased in all patients during treatment, mean BMD only significantly increased at the spine (1.0%\u2009\u00b1\u20093.6%, <jats:italic>p<\/jats:italic>\u2009=\u2009.009). The increase in spine BMD was significantly higher only above post\u2010treatment 25\u2010OH\u2010D levels of 30 ng\u00a0mL<jats:sup>\u22121<\/jats:sup> (2.5% vs. 0.5%, respectively, for 25\u2010OH\u2010D\u2009\u2265\u2009and\u2009&lt;\u200930 ng\u00a0mL<jats:sup>\u22121<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u2009.026). There was a significant decrease in bone resorption (CTX; <jats:italic>p<\/jats:italic>\u2009=\u2009.043) and increased bone formation (P1NP; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) after weight restoration. Nevertheless, a significant increase in PTH was also found, which was inversely correlated with decreased post\u2010treatment 25\u2010OH\u2010D levels (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u2009.153, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Hypovitaminosis D may counteract the efficacy of refeeding in AN through increased bone resorption mediated by secondary hyperparathyroidism, which strongly supports the use of vitamin D supplements for bone health in AN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.22731","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T04:42:48Z","timestamp":1496896968000},"page":"1041-1049","source":"Crossref","is-referenced-by-count":29,"title":["<scp>V<\/scp>itamin D levels strongly influence bone mineral density and bone turnover markers during weight gain in female patients with anorexia nervosa"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9355-7673","authenticated-orcid":false,"given":"Alessandro","family":"Giollo","sequence":"first","affiliation":[{"name":"Department of Medicine Rheumatology Unit, University of Verona Piazzale L.A. 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