{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:04:12Z","timestamp":1792782252046,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T00:00:00Z","timestamp":1498176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Christina Barz Stiftung (Germany)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Assessment of the long\u2010term outcome of anorexia nervosa (AN) in a very large sample of inpatients (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20091,693) and identification of predictors for poor outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Over 25 years (mean 10 years), consecutively admitted inpatients of a specialized hospital were followed. A subsample of 112 patients with 20\u2010year follow\u2010up was defined. Bivariate comparisons and logistic regression analysis identified risk factors of poor outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Body mass index (BMI) increased during the follow\u2010up period. Eating behavior as well as general psychopathology improved but did not reach the level of healthy controls. Remission was found in 30% (total sample) and in 40% (20\u2010year follow\u2010up subsample). Crossover from AN to binge\u2010eating disorder or obesity was rare. The predictors of a negative course of illness included lower BMI at admission; a higher score on the Eating Disorder Inventory Maturity Fears subscale at admission; fewer follow\u2010up years; and higher age at admission. The main diagnostic crossover occurred from AN to eating disorder not otherwise specified. Motherhood was related to better outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Many patients with very severe AN recover from their illness but AN also shows considerable long\u2010term negative consequences. Over long time periods, survivors show improvement but better treatments for severe cases are still needed. Predictors of outcome included symptom severity, chronicity, and length of follow\u2010up but not psychiatric comorbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.22736","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T10:27:58Z","timestamp":1498213678000},"page":"1018-1030","source":"Crossref","is-referenced-by-count":274,"title":["Long\u2010term outcome of anorexia nervosa: Results from a large clinical longitudinal study"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8788-4878","authenticated-orcid":false,"given":"Manfred Maximilian","family":"Fichter","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Ludwig\u2010Maximilians\u2010University (LMU), Munich 80336 Germany"},{"name":"Sch\u00f6n Klinik Roseneck affiliated with the Medical Faculty of the University of Munich (LMU) Prien 83209 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Quadflieg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Ludwig\u2010Maximilians\u2010University (LMU), Munich 80336 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross D.","family":"Crosby","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Research Institute Fargo North Dakota"},{"name":"Department of Psychiatry and Behavioral Science University of North Dakota School of Medicine and Health Sciences Fargo North Dakota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Ludwig\u2010Maximilians\u2010University (LMU), Munich 80336 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,23]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"e1","article-title":"The outcome of Japanese anorexia nervosa patients treated with an inpatient therapy in an internal medicine unit","volume":"17","author":"Amemiya N.","year":"2012","journal-title":"Eating & Weight Disorders"},{"key":"e_1_2_7_3_1","volume-title":"Diagnostic and statistical manual of mental disorders (4th ed. 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