{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:08:46Z","timestamp":1790752126469,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T00:00:00Z","timestamp":1508112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 MH092560"],"award-info":[{"award-number":["K23 MH092560"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK40561"],"award-info":[{"award-number":["P30 DK40561"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 RR025758"],"award-info":[{"award-number":["UL1 RR025758"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Anorexia nervosa is associated with social\u2010emotional functioning deficits and low levels of the social neurohormone oxytocin, even after weight gain. The relationship between low oxytocin levels and social\u2010emotional functioning impairment has not been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We performed a cross\u2010sectional study of 79 women (19 who were less than 85% of ideal body weight [IBW] with anorexia nervosa [AN], 26 who were 90\u2013120% IBW with a history of AN [AN\u2010WR], and 34 who were 90\u2013120% IBW with no eating disorder history [H]). We administered the Eating Disorder Examination\u2013Questionnaire (EDE\u2010Q), Leibowitz Social Anxiety Scale\u2013Self Report (LSAS\u2010SR), Dimensional Assessment of Personality Pathology\u2013Basic Questionnaire (DAPP\u2010BQ; suspiciousness and insecure attachment subscales), and the Toronto Alexithymia Scale (TAS\u201020). We also analyzed fasting serum oxytocin levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most measures of social\u2010emotional functioning showed impairment in women with AN and AN\u2010WR compared to H. Oxytocin levels were low in AN\u2010WR compared to H. Across groups, low oxytocin levels were associated with difficulty identifying feelings (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212.45, <jats:italic>p<\/jats:italic>\u2009=\u2009.008) and overall alexithymia (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212.34, <jats:italic>p<\/jats:italic>\u2009=\u2009.0489).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We speculate that low oxytocin levels may contribute to alexithymia in women with anorexia nervosa.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.22784","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T20:04:29Z","timestamp":1508184269000},"page":"1332-1338","source":"Crossref","is-referenced-by-count":36,"title":["Low oxytocin levels are related to alexithymia in anorexia nervosa"],"prefix":"10.1002","volume":"50","author":[{"given":"Cindy","family":"Schmelkin","sequence":"first","affiliation":[{"name":"Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9721-7817","authenticated-orcid":false,"given":"Franziska","family":"Plessow","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2601-581X","authenticated-orcid":false,"given":"Jennifer J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily K.","family":"Gray","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean A.","family":"Marengi","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reitumetse","family":"Pulumo","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisseth","family":"Silva","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen K.","family":"Miller","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouchine","family":"Hadjikhani","sequence":"additional","affiliation":[{"name":"Department of Radiology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra L.","family":"Franko","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School Boston Massachusetts"},{"name":"Department of Applied Psychology Northeastern University Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamryn T.","family":"Eddy","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Lawson","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.05.040"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.15m10217"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu231"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)90005-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)90006-X"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-4-24"},{"issue":"2","key":"e_1_2_7_9_1","first-page":"107","article-title":"Alexithymia, emotional empathy, and self\u2010regulation in anorexia nervosa","volume":"25","author":"Beadle J. 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