{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T10:53:47Z","timestamp":1778151227553,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T00:00:00Z","timestamp":1508112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH 61836; R01 MH 111263; T32 MH 093311"],"award-info":[{"award-number":["R01 MH 61836; R01 MH 111263; T32 MH 093311"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Longitudinal studies support a prospective relationship between weight suppression (WS) and bulimic syndrome (BN\u2010S) maintenance. Although biobehavioral mechanisms have been proposed to explain this link, such mechanisms have yet to be identified. Given that weight loss would reduce leptin levels which may influence eating, this study examined whether reduced leptin levels mediate the link between greater WS and longer illness duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Women (<jats:italic>N<\/jats:italic>\u00a0=\u00a053), ages 18\u201345\u00a0years, were recruited from the community if they met criteria for a BN\u2010S, including either DSM\u20105 bulimia nervosa (BN; <jats:italic>n<\/jats:italic>\u00a0=\u00a033) or purging disorder (PD: <jats:italic>n<\/jats:italic>\u00a0=\u00a020), and fell within a healthy weight range (18.5\u201326.5\u00a0kg\/m<jats:sup>2<\/jats:sup>). Participants completed clinical assessments and provided blood samples to measure circulating leptin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant associations were found among greater WS, lower leptin concentrations, and longer duration of illness. Mediation analyses using bootstrapping procedures indicated all paths were significant and that leptin mediated the link between WS and illness duration. An alternative model in which longer illness duration contributed to leptin, via greater WS, was not supported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Longitudinal research is needed to support temporal associations and explore behavioral mechanisms linking leptin to illness trajectory.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.22788","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T20:04:44Z","timestamp":1508184284000},"page":"1432-1436","source":"Crossref","is-referenced-by-count":33,"title":["Weight suppression and bulimic syndrome maintenance: Preliminary findings for the mediating role of leptin"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6542-5147","authenticated-orcid":false,"given":"Pamela K.","family":"Keel","sequence":"first","affiliation":[{"name":"Florida State University Tallahassee Florida 32306"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay P.","family":"Bodell","sequence":"additional","affiliation":[{"name":"University of Chicago Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alissa A.","family":"Haedt\u2010Matt","sequence":"additional","affiliation":[{"name":"Illinois Institute of Technology Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana L.","family":"Williams","sequence":"additional","affiliation":[{"name":"Florida State University Tallahassee Florida 32306"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Appelbaum","sequence":"additional","affiliation":[{"name":"Florida State University Tallahassee Florida 32306"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000217"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000077"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.115.1.62"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0013942"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22191"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.08.028"},{"key":"e_1_2_7_8_1","first-page":"317","volume-title":"Binge eating: Nature, assessment, and treatment","author":"Fairburn C. 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