{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:23:41Z","timestamp":1778199821344,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Uric acid is best known for its role in gout\u2014the most prevalent inflammatory arthritis in humans\u2014that is also described as an unusual complication of anorexia nervosa (AN). However, beyond gout, uric acid could also be involved in the pathophysiology and psychopathology of AN, as it has many biological functions serving as a pro\u2010 and antioxidant, neuroprotector, neurostimulant, and activator of the immune response. Further, recent research suggests that uric acid could be a biomarker of mood dysfunction, personality traits, and behavioral patterns. This article discusses the hypothesis that uric acid in AN may not be a mere innocent bystander determined solely by AN behavior and its medical complications. In contrast, the relation between uric acid and AN may have evolutionary origin and may be reciprocal, where uric acid regulates some features and pathophysiological processes of AN, including weight and metabolism regulation, oxidative stress, immunity, mood, cognition, and (hyper)activity.<\/jats:p>","DOI":"10.1002\/eat.22817","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T21:14:45Z","timestamp":1515532485000},"page":"97-101","source":"Crossref","is-referenced-by-count":16,"title":["Anorexia nervosa and uric acid beyond gout: An idea worth researching"],"prefix":"10.1002","volume":"51","author":[{"given":"Mladena","family":"Simeunovic Ostojic","sequence":"first","affiliation":[{"name":"Center for Eating Disorders Helmond, Mental Health Center Region Oost\u2010Brabant, Wesselmanlaan 25a Helmond HA 5707 The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8049-8942","authenticated-orcid":false,"given":"Joyce","family":"Maas","sequence":"additional","affiliation":[{"name":"Center for Eating Disorders Helmond, Mental Health Center Region Oost\u2010Brabant, Wesselmanlaan 25a Helmond HA 5707 The Netherlands"},{"name":"Department of Medical and Clinical Psychology Tilburg University, Warandelaan 2, P.O. 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