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Those individuals with current or recovered from AN had previously shown altered regional cortical volumes across orbitofrontal cortex and insula. A linear relevance vector machine\u2010learning algorithm estimated patterns of regional thickness across 24 subdivisions of those regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Region\u2010based analysis showed higher cortical thickness in AN and REC\u2010AN, compared to controls, in the right medial orbital (olfactory) sulcus, and greater cortical thickness for short insular gyri in REC\u2010AN versus controls bilaterally. The machine\u2010learning algorithm identified a pattern of relatively higher right orbital, right insular and left middle frontal cortical thickness, but lower left orbital, right middle and inferior frontal, and bilateral superior frontal cortical thickness specific to AN versus controls (74% specificity and 74% sensitivity, \u03c7<jats:italic><jats:sup>2<\/jats:sup> p<\/jats:italic>\u2009&lt;\u2009.004); predicted probabilities differed significantly between AN and controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.023). No pattern significantly distinguished the REC\u2010AN group from controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher cortical thickness in medial orbitofrontal cortex and insula probably contributes to higher gray matter volume in AN in those regions. The machine\u2010learning algorithm identified a mixed pattern of mostly higher orbital and insular, but relatively lower superior frontal cortical thickness in individuals with current AN. These novel results suggest that regional cortical thickness patterns could be state markers for AN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.22828","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T15:12:41Z","timestamp":1518016361000},"page":"241-249","source":"Crossref","is-referenced-by-count":57,"title":["Cortical thickness patterns as state biomarker of anorexia nervosa"],"prefix":"10.1002","volume":"51","author":[{"given":"Luca","family":"Lavagnino","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Texas Health Sciences Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benson","family":"Mwangi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Texas Health Sciences Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Texas Health Sciences Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E.","family":"Shott","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Colorado Anschutz Medical Campus Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jair C.","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Texas Health Sciences Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6590-3441","authenticated-orcid":false,"given":"Guido K. 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