{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:52:59Z","timestamp":1760147579418,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,8,18]],"date-time":"2018-08-18T00:00:00Z","timestamp":1534550400000},"content-version":"vor","delay-in-days":48,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH109639"],"award-info":[{"award-number":["R01 MH109639"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Individuals with eating disorders are theorized to have basic impairments in affective appraisal and social\u2013emotional processing that contribute to pathogenesis of the disease. We aimed to determine if facial electromyography could be used to discriminate between happy and disgust emotions during simultaneous acquisition of an fMRI BOLD sequence in efforts to establish a novel tool for investigating emotion\u2010driven hypotheses about eating pathology. In line with standards for rigor and reproducibility, we provide detailed protocols and code to support each step of this project.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Sixteen adolescents with low\u2010weight eating disorders viewed emotional faces (Happy or Disgust) and were asked to mimic their facial expression during simultaneous BOLD and EMG (<jats:italic>Corrugator supercilli, Lavator lavii, Zygomaticus major<\/jats:italic>) acquisition. Trials were repeated with the scanner off and again with scanner on (i.e., fatigue).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:italic>Levator<\/jats:italic> and <jats:italic>Zygomaticus<\/jats:italic> activation patterns discriminated disgust and happy faces successfully. The pattern held between scanner on and off conditions, but muscle activation attenuated in the Fatigue condition, especially for the <jats:italic>Zygomaticus<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Simultaneous fMRI\u2013EMG is a new tool capable of discriminating specific emotions based on muscle activation patterns and can be leveraged to answer emotion\u2010driven hypotheses about clinical populations characterized by difficulty labeling or processing emotions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.22893","type":"journal-article","created":{"date-parts":[[2018,8,18]],"date-time":"2018-08-18T10:43:48Z","timestamp":1534589028000},"page":"722-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Development of a methodology to combine fMRI and EMG to measure emotional responses in patients with anorexia nervosa"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7054-9590","authenticated-orcid":false,"given":"Tom","family":"Hildebrandt","sequence":"first","affiliation":[{"name":"Eating and Weight Disorders Program Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lazar","family":"Fleysher","sequence":"additional","affiliation":[{"name":"Department of Radiology Icahn School of Medicine at Mount Sinai  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor","family":"Griffen","sequence":"additional","affiliation":[{"name":"Eating and Weight Disorders Program Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York New York"},{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Heywood","sequence":"additional","affiliation":[{"name":"Eating and Weight Disorders Program Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3381-986X","authenticated-orcid":false,"given":"Robyn","family":"Sysko","sequence":"additional","affiliation":[{"name":"Eating and Weight Disorders Program Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22498"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2015.12.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05446.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22572"},{"key":"e_1_2_8_6_1","first-page":"173","volume-title":"The handbook of emotion","author":"Cacioppo J. 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