{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:49:42Z","timestamp":1774925382379,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Although abuse of bupropion to achieve euphoria or a stimulant\u2010like effect has been described in the literature, to our knowledge abuse of bupropion XR to control binge eating and reduce appetite by a patient with eating disorder has not been previously reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We report the case of a 22\u2010year\u2010old woman with bulimia nervosa and complex PTSD who abused bupropion XR to doses that at peak reached 3,000\u20134,500\u2009mg\/day. She suffered from adverse effects including headaches, tachycardia, anxiety, insomnia, and, finally, grand mal seizures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Unable to control the abuse on her own, she sought inpatient treatment, following which she remained off bupropion XR for a year. However, she subsequently relapsed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The stimulant, euphoriant, and anorexic effects of bupropion XR contribute to its potential for abuse, particularly among patients with eating disorders. Clinicians are reminded to screen for anorexia nervosa and bulimia nervosa histories prior to prescribing this medication, and to consider its abuse among eating disorder patients presenting with seizures. For patients abusing this medication, motivational interviewing in the context of a strong, ongoing therapeutic relationship might help to achieve sustained periods of abstinence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.22948","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T12:42:24Z","timestamp":1537360944000},"page":"1207-1209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Severe bupropion XR abuse in a patient with long\u2010standing bulimia nervosa and complex PTSD"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0434-2898","authenticated-orcid":false,"given":"Yael","family":"Dagan","sequence":"first","affiliation":[{"name":"The Jerusalem Mental Health Center Kfar Shaul Psychiatric Hospital affiliated with The Hebrew University\u2014Hadassah School of Medicine  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Yager","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine, University of Colorado Denver  Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0b013e3182824863"},{"key":"e_1_2_5_3_1","volume-title":"Wellbutrin prescribing information","author":"FDA, US Food and Drug Administration","year":"2017"},{"issue":"7","key":"e_1_2_5_4_1","first-page":"262","article-title":"Treatment of bulimia with bupropion: A multicenter controlled trial","volume":"49","author":"Horne R. 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