{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:12:40Z","timestamp":1775142760403,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T00:00:00Z","timestamp":1540512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008523","name":"Center for Clinical and Translational Science, University of Illinois at Chicago","doi-asserted-by":"publisher","award":["UL1TR001070"],"award-info":[{"award-number":["UL1TR001070"]}],"id":[{"id":"10.13039\/100008523","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effectiveness and tolerability of omega\u20103 polyunsaturated fatty acid (PUFA) supplementation for treatment of trait anxiety among adolescent females with restrictive anorexia nervosa (AN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A pilot double\u2010blind, placebo\u2010controlled randomized trial of adolescent females with AN (<jats:italic>N<\/jats:italic>\u2009=\u200924) entering Partial Hospitalization Program (PHP) from January 2015 to February 2016. Participants were randomized to four daily PUFA (2,120\u2009mg eicosapentaenoic acid\/600\u2009mg docosohexaenoic acid) or placebo capsules for 12\u2009weeks. A 9\u2010item questionnaire of side effect frequency assessed medication tolerability. The Beck Anxiety Inventory\u2010Trait measured anxiety at baseline, 6, and 12\u2009weeks. Linear mixed models evaluated associations between randomization group and study outcomes. Twenty\u2010two and 18 participants completed 6 and 12\u2009weeks of data collection, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Medication side effect scores were low and were not significantly different between randomization groups at Week 6 (<jats:italic>p<\/jats:italic>\u2009=\u2009.20) or 12 (<jats:italic>p<\/jats:italic>\u2009=\u2009.41). Mean trait anxiety score significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01) decreased from baseline to 12\u2009weeks in both groups, and the rate of change over the course of time did not differ between omega\u20103 PUFA and placebo groups (<jats:italic>p<\/jats:italic>\u2009=\u2009.55).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Omega\u20103 PUFA supplementation was well tolerated in adolescent females with AN. Although power to detect differences was limited, we found no evidence that omega\u20103 PUFA benefited anxiety beyond nutritional restoration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.22964","type":"journal-article","created":{"date-parts":[[2018,10,27]],"date-time":"2018-10-27T05:06:23Z","timestamp":1540616783000},"page":"1367-1372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["A pilot randomized controlled trial of omega\u20103 fatty acid supplementation for the treatment of anxiety in adolescents with anorexia nervosa"],"prefix":"10.1002","volume":"51","author":[{"given":"Brittny E.","family":"Manos","sequence":"first","affiliation":[{"name":"The Research Institute at Nationwide Children's Hospital  Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terrill D.","family":"Bravender","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Michigan  Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tondi M.","family":"Harrison","sequence":"additional","affiliation":[{"name":"The Research Institute at Nationwide Children's Hospital  Columbus Ohio"},{"name":"The Ohio State University  Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah L. 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