{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:48:06Z","timestamp":1768520886552,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>An association between bulimia nervosa (BN) and prolonged corrected QT interval (QTc) in the electrocardiogram has been suggested, but results of previous studies are conflicting, and the risk of cardiac events in patients with BN has yet to be investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We estimated mean QTc interval and relative risk of borderline (QTc &gt;440\u2009ms) and prolonged QTc (QTc &gt;460\u2009ms) between adult women with BN (<jats:italic>N<\/jats:italic>\u2009=\u2009531) and healthy controls (<jats:italic>N<\/jats:italic>\u2009=\u2009123). In follow\u2010up analyses, we investigated the risk of a primary endpoint (syncope, ventricular tachycardia, and cardiac arrest) and all\u2010cause mortality in patients with BN (<jats:italic>N<\/jats:italic>\u2009=\u2009702) compared with a population\u2010based cohort derived from the Danish Civil Register (<jats:italic>N<\/jats:italic>\u2009=\u20097,020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean QTc did not differ between patients with BN and controls. Relative risk of borderline prolonged QTc was 2.3 (<jats:italic>p<\/jats:italic>\u2009=\u20090.28). The number of patients and controls with prolonged QTc was small, and the risk did not differ between patients with BN and controls. Median follow\u2010up was 10.6 years. Although there appeared to be increased risks after 5 years of follow\u2010up, long\u2010term risks of the primary endpoint (Hazard ratio [HR]\u2009=\u20091.4, <jats:italic>p<\/jats:italic>\u2009=\u20090.37) and all\u2010cause mortality (HR\u2009=\u20091.7, <jats:italic>p<\/jats:italic>\u2009=\u2009.28), respectively, were not increased in patients with BN compared to a population\u2010based cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Mean QTc did not differ between patients with BN and healthy controls, and the risk of prolonged QTc was not increased in patients with BN. There was no difference in the long\u2010term risk of cardiac events, and long\u2010term all\u2010cause mortality did not differ significantly between patients with BN and a population\u2010based cohort.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.22984","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T14:00:44Z","timestamp":1544104844000},"page":"1331-1338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The QTc interval and risk of cardiac events in bulimia nervosa: A long\u2010term follow\u2010up study"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3338-9297","authenticated-orcid":false,"given":"Tanja C.","family":"Frederiksen","sequence":"first","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten K.","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Internal Medicine Randers Regional Hospital  Randers Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pernille C.","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine and Rehabilitation Western Hospital Unit  Herning Denmark"},{"name":"Centre for Child and Adolescent Psychiatry Aarhus University Hospital  Risskov Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per H.","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Centre for Child and Adolescent Psychiatry Aarhus University Hospital  Risskov Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Graff","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-8347","authenticated-orcid":false,"given":"Loa","family":"Clausen","sequence":"additional","affiliation":[{"name":"Centre for Child and Adolescent Psychiatry Aarhus University Hospital  Risskov Denmark"},{"name":"Department of Public Health Aarhus University  Aarhus Denmark"},{"name":"Department of Psychology and Behavioral Sciences Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik K.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.30.020179.001131"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.74"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","unstructured":"Buchanan R. Ngwira J. &Amsha K.(2011).Prolonged QT interval in bulimia nervosa.BMJ Case Rep2011.","DOI":"10.1136\/bcr.01.2011.3780"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09020247"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu100"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872014000600016"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811399958"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22249"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2178"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/intjepid\/29.3.495"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.6.3.378"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.07.033"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2017.02.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22503"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2009.10.005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-017-0572-8"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.5.1100"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.03.037"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.014"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2014.07.022"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus359"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012832"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2013.07.042"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03013200"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2008.01753.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000078850"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2013.840568"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.09.055"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2015.03.003"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feat.22984","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.22984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T10:31:06Z","timestamp":1694773866000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.22984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/eat.22984"],"URL":"https:\/\/doi.org\/10.1002\/eat.22984","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"2018-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}