{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:09:04Z","timestamp":1790752144304,"version":"4.1.0"},"reference-count":81,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01MH109782"],"award-info":[{"award-number":["K01MH109782"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005310","name":"Klarman Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["538\u20102013\u20108864"],"award-info":[{"award-number":["538\u20102013\u20108864"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005275","name":"Region Hovedstaden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Alterations in blood lipid concentrations in anorexia nervosa (AN) have been reported; however, the extent, mechanism, and normalization with weight restoration remain unknown. We conducted a systematic review and a meta\u2010analysis to evaluate changes in lipid concentrations in acutely\u2010ill AN patients compared with healthy controls (HC) and to examine the effect of partial weight restoration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A systematic literature review and meta\u2010analysis (PROSPERO: CRD42017078014) were conducted for original peer\u2010reviewed articles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010eight studies were eligible for review; 33 for meta\u2010analyses calculating mean differences (MD). Total cholesterol (MD\u2009=\u200922.7\u2009mg\/dL, 95% CI\u2009=\u200912.5, 33.0), high\u2010density lipoprotein (HDL; MD\u2009=\u20093.4 mg\/dL, CI\u2009=\u20090.3, 7.0), low\u2010density lipoprotein (LDL; MD\u2009=\u200912.2 mg\/dL, CI\u2009=\u20094.4, 20.1), triglycerides (TG; MD\u2009=\u20098.1 mg\/dL, CI\u2009=\u20091.7, 14.5), and apolipoprotein B (Apo B; MD\u2009=\u200911.8 mg\/dL, CI\u2009=\u20092.3, 21.2) were significantly higher in acutely\u2010ill AN than HC. Partially weight\u2010restored AN patients had higher total cholesterol (MD\u2009=\u200914.8 mg\/dL, CI\u2009=\u20092.1, 27.5) and LDL (MD\u2009=\u200916.1 mg\/dL, CI\u2009=\u20092.3, 30.0). Pre\u2010 versus post\u2010weight restoration differences in lipid concentrations did not differ significantly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>We report aggregate evidence for elevated lipid concentrations in acutely\u2010ill AN patients compared with HC, some of which persist after partial weight restoration. This could signal an underlying adaptation or dysregulation not fully reversed by weight restoration. Although concentrations differed between AN and HC, most lipid concentrations remained within the reference range and meta\u2010analyses were limited by the number of available studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.23051","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T10:41:23Z","timestamp":1553769683000},"page":"611-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Increased lipid and lipoprotein concentrations in anorexia nervosa: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1011-5165","authenticated-orcid":false,"given":"Alia A.","family":"Hussain","sequence":"first","affiliation":[{"name":"Eating Disorder Unit Mental Health Center Ballerup  Ballerup Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen 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K.","family":"St\u00f8ving","sequence":"additional","affiliation":[{"name":"Nutrition Clinic, Center for Eating Disorders Odense University Hospital &amp; Psychiatric Services in the Region of Southern Denmark, University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7772-3264","authenticated-orcid":false,"given":"Cynthia M.","family":"Bulik","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Solna Sweden"},{"name":"Department of Psychiatry University of North Carolina at Chapel Hill  North Carolina USA"},{"name":"Department of Nutrition University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2060-1914","authenticated-orcid":false,"given":"Jan 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