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Analysis was carried out also at the end of recovery from the ABA condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the end of the ABA induction phase, 2\u2010AG was significantly decreased in ABA rats in different brain areas but not in the caudato putamen. No changes were detected in AEA levels in any region, whereas the levels of OEA and PEA were decreased exclusively in the hippocampus and hypothalamus. Furthermore, CB1R density was decreased in the dentate gyrus of hippocampus and in the lateral hypothalamus. After recovery, both 2\u2010AG levels and CB1R density were partially normalized in some areas. In contrast, AEA levels became markedly reduced in all the analyzed areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These data demonstrate an altered brain eCB tone in ABA rats, further supporting the involvement of an impaired eCB system in AN pathophysiology that may contribute to the maintenance of some symptomatic aspects of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23157","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T05:29:22Z","timestamp":1566970162000},"page":"1251-1262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Impaired brain endocannabinoid tone in the activity\u2010based model of anorexia nervosa"],"prefix":"10.1002","volume":"52","author":[{"given":"Roberto","family":"Collu","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology University of Cagliari  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8652-9594","authenticated-orcid":false,"given":"Maria","family":"Scherma","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology University of Cagliari  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Piscitelli","sequence":"additional","affiliation":[{"name":"Endocannabinoid Research Group Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche  Pozzuoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Giunti","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology University of Cagliari  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Satta","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology University of Cagliari  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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