{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:28:42Z","timestamp":1784309322935,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Major depressive disorder (MDD) is common in anorexia nervosa (AN), associated with worse outcome and greater suicide risk. Electroconvulsive therapy (ECT) is highly effective in the treatment of MDD refractory to antidepressive treatment. We describe a case series of female adolescents with AN receiving ECT for MDD resistant to treatment and\/or with severe suicide risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We retrospectively analyzed the files of all 30 adolescent females hospitalized in our department because of AN between 1998 and 2017 and treated with ECT. Severity of eating disorder (ED) and depressive symptoms was retrospectively assessed using the Clinical Global Impression\u2010Severity Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients were severely depressed and suicidal on admission. All were resistant to antidepressants. A significant deterioration in depression, with severe suicidality, occurred from admission to pre\u2010ECT, with concomitant improvement in ED symptoms and increase in body mass index (BMI). Significant improvement in depressive and ED symptoms and increase in BMI occurred following ECT, continuing to discharge. Adverse effects were mostly minimal. Fifty\u2010three percentage of the patients were rehospitalized within the first year after ECT, mostly because of deterioration of depression and attempted suicide. Several years after discharge, 46.6% of the patients had no evidence of depression, suicidality, and ED\u2010symptomatology, and another 23% had only evidence of ED symptomatology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>ECT is safe and well tolerated in AN with severe comorbid treatment resistant MDD and\/or with increased suicide risk. Many AN patients undergoing ECT may be remitted at long\u2010term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23181","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T16:11:08Z","timestamp":1571760668000},"page":"210-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A retrospective case series of electroconvulsive therapy in the management of comorbid depression and anorexia nervosa"],"prefix":"10.1002","volume":"53","author":[{"given":"Tal","family":"Shilton","sequence":"first","affiliation":[{"name":"Pediatric Psychosomatic Department, Division of Child and Adolescent Psychiatry, Edmond and Lily Safra Children's Hospital Chaim Sheba Medical Center  Tel Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Enoch\u2010Levy","sequence":"additional","affiliation":[{"name":"Pediatric Psychosomatic Department, Division of Child and Adolescent Psychiatry, Edmond and Lily Safra Children's Hospital Chaim Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanai","family":"Giron","sequence":"additional","affiliation":[{"name":"Pediatric Psychosomatic Department, Division of Child and Adolescent Psychiatry, Edmond and Lily Safra Children's Hospital Chaim Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Yaroslavsky","sequence":"additional","affiliation":[{"name":"Pediatric Psychosomatic Department, Division of Child and Adolescent Psychiatry, Edmond and Lily Safra Children's Hospital Chaim Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revital","family":"Amiaz","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Psychiatry Chaim Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Gothelf","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Child and Adolescent Psychiatric Outpatient Service, Division of Child and Adolescent Psychiatry, Edmond and Lily Safra Children's Hospital Chaim Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Weizman","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Felsenstein Medical Research Center Rabin Campus  Petach Tiqva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6438-1664","authenticated-orcid":false,"given":"Daniel","family":"Stein","sequence":"additional","affiliation":[{"name":"Pediatric Psychosomatic Department, Division of Child and Adolescent Psychiatry, Edmond and Lily Safra Children's Hospital Chaim Sheba Medical Center  Tel Hashomer Israel"},{"name":"Department of Psychiatry Chaim Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_6_3_1","first-page":"4","article-title":"Treatment of patients with eating disorders, third edition","volume":"163","author":"American Psychiatric Association","year":"2006","journal-title":"American Journal of Psychiatry"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCT.0000000000000418"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2014.2422"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.120.10.1023"},{"issue":"6","key":"e_1_2_6_8_1","first-page":"552","article-title":"Anorexia nervosa, 94\u2010year\u2010old woman treated with electroshock","volume":"55","author":"Bernstein I. 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