{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:04:21Z","timestamp":1792782261030,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Psychiatric Research Fund of the Region of Southern DenmarkAction Editor: Guido Frank","id":[{"id":"https:\/\/ror.org\/0290a6k23","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Eating disorders (EDs) are associated with decreased bone mineral density (BMD) and increased fracture risk. The association between BMD and fracture risk in EDs is not well elucidated. We aimed to assess BMD in an ED cohort of patients with active disease and patients in remission, and to assess the predictive value of BMD on incidence of fractures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We included 344 female patients (median age 19, IQR 16; 24) referred to ED treatment. Later, patients were invited to follow\u2010up including assessment of remission status and a dual\u2010energy x\u2010ray absorptiometry (DXA)\u2010scan. Information on fractures was obtained through the Danish National Registry of Patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with current anorexia nervosa (AN) had significantly lower BMD compared to controls at lumbar spine (16% lower,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001), femoral neck (18% lower,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001), and total hip (23% lower,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001). Recovered AN patients had higher BMD compared to those with current disease (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001 for all measures), but lower BMD compared to controls at lumbar spine (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01) and hip (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). BMD did not differ between BN patients and controls. In patients with active eating disorders not otherwise specified, BMD was lower only at the total hip (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.005). We found no association between BMD and fracture risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We confirm that AN is associated with low BMD, whereas BN is not. Remission is associated with higher BMD compared to patients with active AN, but a deficit remains. We found no significant association between BMD and fracture risk, challenging the benefit of the widespread use of DXA scans in young women with ED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      The study is registered in\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      , number NCT00267228.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.23245","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T07:01:41Z","timestamp":1581490901000},"page":"595-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Assessment of fracture risk in women with eating disorders: The utility of dual\u2010energy x\u2010ray absorptiometry (DXA)\u2014Clinical cohort study"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8156-2424","authenticated-orcid":false,"given":"Jacob","family":"Fr\u00f8lich","sequence":"first","affiliation":[{"name":"Centre for Eating Disorders Odense University Hospital  Odense Denmark"},{"name":"Elite Research Center for Medical Endocrinology Odense University Hospital  Odense Denmark"},{"name":"OPEN, Institute of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Mental Health Department of Child and Adolescence Psychiatry, Mental Health Service in the Region of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Al\u2010Dakhiel","family":"Winkler","sequence":"additional","affiliation":[{"name":"Centre for Eating Disorders Odense University Hospital  Odense Denmark"},{"name":"Mental Health Department of Child and Adolescence Psychiatry, Mental Health Service in the Region of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Abrahamsen","sequence":"additional","affiliation":[{"name":"OPEN, Institute of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Medicine Holb\u00e6k Hospital  Holb\u00e6k Denmark"},{"name":"Nuffield Department of Orthopaedics and Rheumatology and Musculoskeletal Sciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Bilenberg","sequence":"additional","affiliation":[{"name":"OPEN, Institute of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Mental Health Department of Child and Adolescence Psychiatry, Mental Health Service in the Region of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne P.","family":"Hermann","sequence":"additional","affiliation":[{"name":"Elite Research Center for Medical Endocrinology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4255-5544","authenticated-orcid":false,"given":"Ren\u00e9 K.","family":"St\u00f8ving","sequence":"additional","affiliation":[{"name":"Centre for Eating Disorders Odense University Hospital  Odense Denmark"},{"name":"Elite Research Center for Medical Endocrinology Odense University Hospital  Odense Denmark"},{"name":"OPEN, Institute of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Mental Health Department of Child and Adolescence Psychiatry, Mental Health Service in the Region of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2104"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-108X(200001)27:1<29::AID-EAT3>3.0.CO;2-P"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.01.369"},{"issue":"1","key":"e_1_2_9_6_1","first-page":"S5","article-title":"The importance and relevance of peak bone mass in the prevalence of osteoporosis","volume":"51","author":"Bonjour J. 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