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These maladaptive food choices may involve fronto\u2010limbic circuitry associated with cognitive control, habit, and reward. We assessed whether high\u2010frequency repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (DLPFC) influenced food\u2010related choice behavior in patients with severe, enduring (SE)\u2010AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Thirty\u2010four females with SE\u2010AN completed a Food Choice Task before and after 20 sessions of real or sham rTMS treatment and at a 4\u2010month follow\u2010up. During the task, participants rated high\u2010 and low\u2010fat food items for healthiness and tastiness and then made a series of choices between a neutral\u2010rated food and high\u2010 and low\u2010fat foods. Outcomes included the proportion of high\u2010fat and self\u2010controlled choices made. A comparison group of 30 healthy women completed the task at baseline only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline data were consistent with previous findings: relative to healthy controls, SE\u2010AN participants showed a preference for low\u2010fat foods and exercised self\u2010control on a greater proportion of trials. There was no significant effect of rTMS treatment nor time on food choices related to fat content. However, among SE\u2010AN participants who received real rTMS, there was a decrease in self\u2010controlled food choices at post\u2010treatment, relative to baseline. Specifically, there was an increase in the selection of tasty\u2010unhealthy foods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In SE\u2010AN, rTMS may promote more flexibility in relation to food choice. This may result from neuroplastic changes in the DLPFC and\/or in associated brain areas.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23267","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T10:57:48Z","timestamp":1587380268000},"page":"1326-1336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["The effect of repetitive transcranial magnetic stimulation on food choice\u2010related self\u2010control in patients with severe, enduring anorexia nervosa"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0898-1926","authenticated-orcid":false,"given":"Bethan","family":"Dalton","sequence":"first","affiliation":[{"name":"Section of Eating Disorders, Department of Psychological Medicine Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5804-9312","authenticated-orcid":false,"given":"Karin","family":"Foerde","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University Irving Medical Center and New York State Psychiatric Institute  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4083-5809","authenticated-orcid":false,"given":"Savani","family":"Bartholdy","sequence":"additional","affiliation":[{"name":"Section of Eating Disorders, Department of Psychological Medicine Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2030-084X","authenticated-orcid":false,"given":"Jessica","family":"McClelland","sequence":"additional","affiliation":[{"name":"Section of Eating Disorders, Department of Psychological Medicine Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kekic","sequence":"additional","affiliation":[{"name":"Section of Eating Disorders, Department of Psychological Medicine Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2821-314X","authenticated-orcid":false,"given":"Luiza","family":"Grycuk","sequence":"additional","affiliation":[{"name":"Section of Eating Disorders, Department of Psychological Medicine Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain C.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Section of Eating Disorders, Department of Psychological Medicine Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Section of Eating Disorders, Department of Psychological Medicine Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"},{"name":"South London and Maudsley NHS Foundation Trust Maudsley Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8434-8212","authenticated-orcid":false,"given":"Joanna E.","family":"Steinglass","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University Irving Medical Center and New York State Psychiatric Institute  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12024"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00328"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-015-1069-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22732"},{"key":"e_1_2_9_7_1","unstructured":"Bates D. 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