{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:00:04Z","timestamp":1792612804785,"version":"4.5.0"},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"crossref","award":["391362"],"award-info":[{"award-number":["391362"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>People who are ill with anorexia nervosa (AN) show altered availability of key plasma nutrients. However, little is known about the patterning of alterations that occurs across diverse nutrients during active phases of illness or about the persistence of any such alterations following remission of illness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We compared plasma levels of one\u2010carbon metabolism nutrients across women with active AN (AN\u2010Active: <jats:italic>n<\/jats:italic> = 53), in remission from AN (AN\u2010Remitted: <jats:italic>n<\/jats:italic> = 40), or who had no eating\u2010disorder history (NED: <jats:italic>n<\/jats:italic> = 36). We also tested associations between body mass index (BMI) changes and changes in pre\u2010 to posttreatment nutrient levels, and explored the association between nutrient levels, on the one hand, and BMI and eating symptoms, on the other. Choline, betaine, and methionine were analyzed using mass spectrometry. Folate and B12 were analyzed using the AccuBind\u00ae ELISA kit. Eating\u2010disorder symptoms were assessed by interview and self\u2010report.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to NED individuals, AN\u2010Active individuals exhibited significantly elevated B12 and (less\u2010reliably) betaine. In AN\u2010Active individuals, lower BMI was associated with higher B12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The observed alterations run contrary to the intuition that plasma nutrient levels should be directly responsive to nutritional status and suggest, instead, the existence of compensatory adaptations to malnutrition in individuals with active AN. Further study is required to clarify mechanisms that underlie such effects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23292","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T20:12:59Z","timestamp":1589919179000},"page":"1534-1538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Plasma levels of o<scp>ne\u2010carbon<\/scp> metabolism nutrients in women with anorexia nervosa"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2102-5859","authenticated-orcid":false,"given":"Jessica","family":"Burdo","sequence":"first","affiliation":[{"name":"Eating Disorders Program Douglas University Institute  Montreal Quebec Canada"},{"name":"Department of Psychiatry McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0863-8098","authenticated-orcid":false,"given":"Linda","family":"Booij","sequence":"additional","affiliation":[{"name":"Department of Psychiatry McGill University  Montreal Quebec Canada"},{"name":"Department of Psychology Concordia University  Montreal Quebec Canada"},{"name":"Sainte\u2010Justine Hospital Research Centre University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Kahan","sequence":"additional","affiliation":[{"name":"Eating Disorders Program Douglas University Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3984-1240","authenticated-orcid":false,"given":"Lea","family":"Thaler","sequence":"additional","affiliation":[{"name":"Eating Disorders Program Douglas University Institute  Montreal Quebec Canada"},{"name":"Department of Psychiatry McGill University  Montreal Quebec Canada"},{"name":"Research Centre Douglas University Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0962-3514","authenticated-orcid":false,"given":"Mimi","family":"Isra\u00ebl","sequence":"additional","affiliation":[{"name":"Eating Disorders Program Douglas University Institute  Montreal Quebec Canada"},{"name":"Department of Psychiatry McGill University  Montreal Quebec Canada"},{"name":"Research Centre Douglas University Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2209-8702","authenticated-orcid":false,"given":"Luis B.","family":"Agellon","sequence":"additional","affiliation":[{"name":"School of Human Nutrition McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Nitschmann","sequence":"additional","affiliation":[{"name":"School of Human Nutrition McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5738-3853","authenticated-orcid":false,"given":"Linda","family":"Wykes","sequence":"additional","affiliation":[{"name":"School of Human Nutrition McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4887-7824","authenticated-orcid":false,"given":"Howard","family":"Steiger","sequence":"additional","affiliation":[{"name":"Eating Disorders Program Douglas University Institute  Montreal Quebec Canada"},{"name":"Department of Psychiatry McGill University  Montreal Quebec Canada"},{"name":"Research Centre Douglas University Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-016-0215-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.03.003"},{"issue":"2","key":"e_1_2_8_4_1","first-page":"9","article-title":"Resistance and metabolic syndrome, and body fat composition; primary care\u2010based study","volume":"10","author":"Baltaci D.","year":"2013","journal-title":"Medicinski Glasnik"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337-017-0158-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860710202600157"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22371"},{"key":"e_1_2_8_8_1","volume-title":"Eating disorder examination (16.0D)","author":"Fairburn C. G.","year":"2008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11040792"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135268"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20361"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611726200"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1600625"},{"key":"e_1_2_8_14_1","unstructured":"World Health Organization. (1995).Physical status: The use of and interpretation of anthropometry. Report of a WHO Expert Committee."}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feat.23292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.23292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/eat.23292","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.23292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T21:13:05Z","timestamp":1693689185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.23292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,19]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/eat.23292"],"URL":"https:\/\/doi.org\/10.1002\/eat.23292","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,19]]},"assertion":[{"value":"2020-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}