{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:54:19Z","timestamp":1790747659481,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies have shown elevated cancer risk in anorexia nervosa but the literature on other eating disorders (EDs) is scarce. This study aimed to investigate the association between all EDs and esophageal, stomach, and other cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a retrospective cohort design, based on a two\u2010million randomized longitudinal health insurance dataset, a sub\u2010dataset of Taiwan's National Health Insurance Research Database. From all the potential participants aged 20\u2009years or more, a total of 6,628 participants were enrolled, including 1,657 patients with EDs, with sex\u2010, age\u2010, and indexed date\u2010matched (1:3) 4,971 controls. Each participant was individually tracked from 2000 to 2015 to identify incident cases of cancers, including esophageal cancer (EC), stomach cancer (SC), and all other cancers (AOC). The multivariate Cox proportional hazards model was employed to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between EDs and cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the total 6,628 enrollees, 222 in 1,657 individuals with EDs and 810 in the 4,971 non\u2010ED control individuals developed cancer (1,262.40 vs. 1,472.15 per 100,000 person\u2010years), and the Kaplan\u2013Meier survival analysis was not statistically significant (log\u2010rank,<jats:italic>p<\/jats:italic>\u00a0=\u00a0.324). However, after adjusting for covariates, the risk of EC and SC among the individuals with an ED was significantly higher, with adjusted HRs of 5.32 (95% CI: 1.07\u201326.49,<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and 4.61 (95% CI: 1.91\u201311.14,<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), respectively. EDs were not associated with other cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides evidence for the association between EDs and the risk for EC and SC. Further research on mechanisms and prevention is therefore needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23367","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T06:47:09Z","timestamp":1622875629000},"page":"959-968","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Eating disorders and the risk of esophageal and stomach<scp>cancers\u2010A<\/scp>nationwide, population\u2010based cohort study in Taiwan"],"prefix":"10.1002","volume":"54","author":[{"given":"Hui\u2010Wen","family":"Yeh","sequence":"first","affiliation":[{"name":"Institute of Bioinformatics and System Biology, National Chiao\u2010Tung University Hsin\u2010Chu Taiwan, Republic of China"},{"name":"Department of Psychiatry Tri\u2010Service General Hospital, School of Medicine, National Defense Medical Center Taipei Taiwan, Republic of China"},{"name":"Department of Nursing Tri\u2010Service General Hospital, and School of Nursing, National Defense Medical Center Taipei Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu\u2010Chien","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Medical Research Tri\u2010Service General Hospital, National Defense Medical Center Taipei Taiwan, Republic of China"},{"name":"School of Public Health, National Defense Medical Center Taipei Taiwan, Republic of China"},{"name":"Graduate Institute of Life Sciences, National Defense Medical Center Taipei Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Hsiang","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Medical Research Tri\u2010Service General Hospital, National Defense Medical Center Taipei Taiwan, Republic of China"},{"name":"School of Public Health, National Defense Medical Center Taipei Taiwan, Republic of China"},{"name":"Taiwanese Injury Prevention and Safety Promotion Association Taipei Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010An","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tri\u2010Service General Hospital, School of Medicine, National Defense Medical Center Taipei Taiwan, Republic of China"},{"name":"Student Counseling Center, National Defense Medical Center Taipei Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chen","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tri\u2010Service General Hospital, School of Medicine, National Defense Medical Center Taipei Taiwan, Republic of China"},{"name":"Department of Psychiatry Tri\u2010Service General Hospital, Song\u2010Shan Branch, National Defense Medical Center Taipei Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian\u2010Sheng","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tri\u2010Service General Hospital, School of Medicine, National Defense Medical Center Taipei Taiwan, Republic of China"},{"name":"Student Counseling Center, National Defense Medical Center Taipei Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-017-2287-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4618-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2015.02.009"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.5313"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089867"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.12.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.07.075"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2087"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20140076"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756284819834511"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","unstructured":"Chien W. 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