{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:03:57Z","timestamp":1778691837216,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T00:00:00Z","timestamp":1604707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to compare the outcomes of higher calorie refeeding (HCR) and a lower calorie refeeding (LCR) methods among a diverse sample of young Asian adolescents admitted to a tertiary institution in Asia for management of anorexia nervosa (AN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This is a retrospective case control study of Asian adolescents who were managed using an inpatient HCR protocol (2016\u20132017) and an LCR protocol (2010\u20132014). Baseline characteristics, daily change in percent median body mass index (%mBMI), and rates of refeeding hypophosphatemia were analyzed between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 125 adolescents with AN were analyzed with 61 (52%) patients in the HCR group. Mean age was 14.0\u2009years (<jats:italic>SD<\/jats:italic> =1.5) and mean presenting %mBMI was 73.2 (<jats:italic>SD<\/jats:italic> =6.9) with mean length of stay of 11.9\u2009days (<jats:italic>SD<\/jats:italic> =\u20096.6). Patients in the HCR group had significantly increased rate of change of %mBMI (<jats:italic>M\u2009=<\/jats:italic> 0.39, <jats:italic>SD\u2009=<\/jats:italic> 0.31) than patients in the LCR group (<jats:italic>M<\/jats:italic> =\u20090.12, <jats:italic>SD<\/jats:italic> =\u20090.43) (<jats:italic>p<\/jats:italic> &lt;\u2009.001). There was an increased rate of mild hypophosphatemia in the HCR group (HCR: 46%, LCR: 22%, <jats:italic>p<\/jats:italic> =\u2009.007) but no difference in rates of moderate hypophosphatemia and no cases of severe hypophosphataemia. Lower presenting %mBMI significantly predicted the phosphate levels (<jats:italic>p<\/jats:italic> =\u2009.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In a sample of Asian adolescents with AN, use of an HCR protocol was associated with improved rate of inpatient weight gain. There was increased risk of mild hypophosphataemia, but not moderate to severe hypophosphataemia, suggesting that an HCR protocol can be used safely with close monitoring of phosphate levels.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23403","type":"journal-article","created":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T13:21:41Z","timestamp":1604755301000},"page":"95-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Outcomes of a higher calorie inpatient refeeding protocol in Asian adolescents with anorexia nervosa"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9439-1000","authenticated-orcid":false,"given":"Courtney","family":"Davis","sequence":"first","affiliation":[{"name":"Adolescent Medicine Service KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei Jie Nicholas","family":"Hong","sequence":"additional","affiliation":[{"name":"KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella Letian","family":"Zhang","sequence":"additional","affiliation":[{"name":"KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei Ern Grace","family":"Quek","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie Kai Ethel","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Yin","family":"Oh","sequence":"additional","affiliation":[{"name":"Adolescent Medicine Service KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumudhini","family":"Rajasegaran","sequence":"additional","affiliation":[{"name":"Adolescent Medicine Service KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0479-2415","authenticated-orcid":false,"given":"Chu Shan Elaine","family":"Chew","sequence":"additional","affiliation":[{"name":"Adolescent Medicine Service KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_3_1","article-title":"First presentation of restrictive early onset eating disorders in Asian children","author":"Chew C. S. E.","year":"2020","journal-title":"International Journal of Eating Disorders"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337-017-0139-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2013.07.014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2011.06.011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22482"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2014.10.259"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2013.05.014"},{"key":"e_1_2_9_10_1","volume-title":"Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids (Macronutrients).","author":"Institute of Medicine","year":"2005"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22472"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2014.06.010"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/410971"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(200103)29:2<224::AID-EAT1012>3.0.CO;2-R"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1363461512459487"},{"key":"e_1_2_9_16_1","volume-title":"Calculation of effect sizes","author":"Lenhard W.","year":"2016"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.496"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20634"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337-016-0132-0"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533613476892"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533615627267"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337-017-0134-6"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22390"},{"key":"e_1_2_9_24_1","volume-title":"Percentiles of Body Mass Index\u2010for\u2010age Anthropometric Study on School Children in Singapore","author":"Singapore Government Health Promotion Board","year":"2002"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2009.11.207"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16152747"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23177"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.23403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/eat.23403","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.23403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T13:17:40Z","timestamp":1693747060000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.23403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,7]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/eat.23403"],"URL":"https:\/\/doi.org\/10.1002\/eat.23403","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,7]]},"assertion":[{"value":"2020-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}