{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:58:24Z","timestamp":1790517504579,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009560","name":"American Gastroenterological Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Little research exists on Rome IV disorders of gut\u2013brain interaction (DGBI; formerly called functional gastrointestinal disorders) in outpatients with eating disorders (EDs). These data are particularly lacking for avoidant\/restrictive food intake disorder (ARFID), which shares core features with DGBI. We aimed to identify the frequency and nature of DGBI symptoms among outpatients with EDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Consecutively referred pediatric and adult patients diagnosed with an ED (<jats:italic>n<\/jats:italic>\u00a0=\u00a0168, 71% female, ages 8\u201376\u2009years) in our tertiary care ED program between March 2017 and July 2019 completed a modified Rome IV Questionnaire for DGBI and psychopathology measure battery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority (<jats:italic>n<\/jats:italic>\u00a0=\u00a0122, 72%) of participants reported at least one bothersome gastrointestinal symptom. Sixty\u2010six (39%) met criteria for a DBGI, most frequently functional dyspepsia\u2014post\u2010prandial distress syndrome subtype (31%). DGBI were surprisingly less frequent among patients with ARFID (30%) versus EDs that are associated with shape or weight concerns (45%; <jats:italic>X<\/jats:italic><jats:sup>2<\/jats:sup>[1]\u00a0=\u00a03.61, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.058, Cramer's <jats:italic>V<\/jats:italic>\u00a0=\u00a0.147). Among those with ARFID, DGBI presence was associated with the fear of aversive consequences prototype and multiple comorbid prototype presence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We demonstrated notable overlap between DGBI and EDs, particularly post\u2010prandial distress symptoms. Further research is needed to examine if gastrointestinal symptoms predict or are a result of greater ED pathology, including ARFID prototypes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23414","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T07:04:31Z","timestamp":1606460671000},"page":"952-958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Disorders of gut\u2013brain interaction common among outpatients with eating disorders including avoidant\/restrictive food intake disorder"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2059-3256","authenticated-orcid":false,"given":"Helen Burton","family":"Murray","sequence":"first","affiliation":[{"name":"Center for Neurointestinal Health, Gastroenterology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Eating Disorders Clinical and Research Program, Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braden","family":"Kuo","sequence":"additional","affiliation":[{"name":"Center for Neurointestinal Health, Gastroenterology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1586-0930","authenticated-orcid":false,"given":"Kamryn T.","family":"Eddy","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Breithaupt","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8946-9977","authenticated-orcid":false,"given":"Kendra R.","family":"Becker","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1466-0873","authenticated-orcid":false,"given":"Melissa J.","family":"Dreier","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2601-581X","authenticated-orcid":false,"given":"Jennifer J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Staller","sequence":"additional","affiliation":[{"name":"Center for Neurointestinal Health, Gastroenterology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30003-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2008.06.012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510015836"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01576.x"},{"issue":"1","key":"e_1_2_8_6_1","first-page":"88","article-title":"Gastrointestinal symptoms in bulimia nervosa: effects of treatment","volume":"90","author":"Chami T. 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