{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:20:56Z","timestamp":1770697256978,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007137","name":"Helse Nord RHF","doi-asserted-by":"publisher","award":["PFP1140\u201013"],"award-info":[{"award-number":["PFP1140\u201013"]}],"id":[{"id":"10.13039\/501100007137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["229142"],"award-info":[{"award-number":["229142"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Reduction in cerebral volume is often found in underweight patients with anorexia nervosa (AN), but few studies have investigated other morphological measures. Cortical thickness (CTh) and surface area (CSA), often used to produce the measure of cortical volume, are developmentally distinct measures that may be differentially affected in AN, particularly in the developing brain. In the present study, we investigated CTh and CSA both separately and jointly to gain further insight into structural alterations in adolescent AN patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Thirty female AN inpatients 12\u201318\u2009years of age, and 27 age\u2010matched healthy controls (HC) underwent structural magnetic resonance imaging. Group differences in CTh and CSA were investigated separately and jointly with a permutation\u2010based nonparametric combination method (NPC) which may be more sensitive in detecting group differences compared to traditional volumetric methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results showed significant reduction in in both CTh and CSA in several cortical regions in AN compared to HC and the reduction was related to BMI. Different results for the two morphological measures were found in a small number of cortical regions. The joint NPC analyses showed significant group differences across most of the cortical mantle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Results from this study give novel insight to areal reduction in adolescent AN patients and indicate that both CTh and CSA reduction is related to BMI. The study is the first to use the NPC method to reveal large structural alterations covering most of the brain in adolescent AN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23448","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T06:59:39Z","timestamp":1608274779000},"page":"561-568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cerebral cortical thickness and surface area in adolescent anorexia nervosa: Separate and joint analyses with a permutation\u2010based nonparametric method"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4795-201X","authenticated-orcid":false,"given":"Anna D.","family":"Myrvang","sequence":"first","affiliation":[{"name":"Department of psychology, Faculty of Health Sciences UiT The Artic University of Norway Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torgil R.","family":"Vangberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University Hospital of North Norway Troms\u00f8 Norway"},{"name":"PET Center University Hospital of North Norway Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Stedal","sequence":"additional","affiliation":[{"name":"Regional Department for Eating Disorders, Division of Mental Health and Addiction Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d8yvind","family":"R\u00f8","sequence":"additional","affiliation":[{"name":"Regional Department for Eating Disorders, Division of Mental Health and Addiction Oslo University Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tor","family":"Endestad","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Social Sciences University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan H.","family":"Rosenvinge","sequence":"additional","affiliation":[{"name":"Department of psychology, Faculty of Health Sciences UiT The Artic University of Norway Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per M.","family":"Aslaksen","sequence":"additional","affiliation":[{"name":"Department of psychology, Faculty of Health Sciences UiT The Artic University of Norway Troms\u00f8 Norway"},{"name":"Regional Center for Eating Disorders University Hospital of North Norway Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2013.03.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-7358(88)90050-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.02.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-39-14"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-11-179"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_8_9_1","volume-title":"Cognitive behavior therapy and eating disorders","author":"Fairburn C. 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