{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:33:18Z","timestamp":1785429198881,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study examined the feasibility, safety, and potential efficacy of lisdexamfetamine (LDX) as a treatment for adults with bulimia nervosa (BN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>An open\u2010label 8\u2010week feasibility study was conducted in participants with BN. Enrollment rate, dropout rate, safety outcomes, and eating disorder symptom change were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen of 23 participants completed the study per protocol. There was no participant\u2010initiated dropout due to adverse drug reactions and no severe and unexpected adverse drug reactions. An average increase in heart rate of 12.1 beats\/min was observed. There was a mean weight reduction of 2.1 kg and one participant was withdrawn for clinically significant weight loss. In the intent\u2010to\u2010treat sample, there were reductions in objective binge episodes and compensatory behaviors from Baseline to Post\/End\u2010of\u2010Treatment (mean difference = \u221229.83, 95% confidence interval: \u221243.38 to \u221216.27; and mean difference = \u221233.78, 95% confidence interval: \u221248.74 to \u221218.82, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Results of this study indicate that a randomized controlled trial would be feasible with close monitoring of certain safety parameters (especially over a longer time period as long\u2010term safety is unknown). However, the results should not be used as evidence for clinicians to prescribe LDX to individuals with BN before its efficacy and safety are properly tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration Number<\/jats:title><jats:p>NCT03397446.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23480","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T14:17:12Z","timestamp":1612621032000},"page":"872-878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A feasibility study evaluating lisdexamfetamine dimesylate for the treatment of adults with bulimia nervosa"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0462-9749","authenticated-orcid":false,"given":"Aaron R.","family":"Keshen","sequence":"first","affiliation":[{"name":"Eating Disorder Program, Nova Scotia Health Authority  Halifax Nova Scotia Canada"},{"name":"Department of Psychiatry Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Dixon","sequence":"additional","affiliation":[{"name":"Eating Disorder Program, Nova Scotia Health Authority  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1459-7472","authenticated-orcid":false,"given":"Sarrah I.","family":"Ali","sequence":"additional","affiliation":[{"name":"Eating Disorder Program, Nova Scotia Health Authority  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Helson","sequence":"additional","affiliation":[{"name":"Eating Disorder Program, Nova Scotia Health Authority  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4955-9150","authenticated-orcid":false,"given":"Abraham","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Milliken","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Gamberg","sequence":"additional","affiliation":[{"name":"Eating Disorder Program, Nova Scotia Health Authority  Halifax Nova Scotia Canada"},{"name":"Department of Psychiatry Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Sadek","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5077-2787","authenticated-orcid":false,"given":"Allan","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health, Department of Psychiatry Institute of Medical Science, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8879-0865","authenticated-orcid":false,"given":"Susan L.","family":"McElroy","sequence":"additional","affiliation":[{"name":"Lindner Center of HOPE  Mason Ohio USA"},{"name":"Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(02)01045-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eatbeh.2015.05.012"},{"key":"e_1_2_8_4_1","unstructured":"Fairburn C. 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