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No genome\u2010wide studies of other eating disorders, such as bulimia nervosa and binge\u2010eating disorder, have been performed, despite their substantial heritability. Exploratively, we aimed to identify traits that are genetically associated with binge\u2010type eating disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We calculated genome\u2010wide polygenic scores for 269 trait and disease outcomes using PRSice v2.2 and their association with anorexia nervosa, bulimia nervosa, and binge\u2010eating disorder in up to 640 cases and 17,050 controls from the UK Biobank. Significant associations were tested for replication in the Avon Longitudinal Study of Parents and Children (up to 217 cases and 3,018 controls).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Individuals with binge\u2010type eating disorders had higher polygenic scores than controls for other psychiatric disorders, including depression, schizophrenia, and attention deficit hyperactivity disorder, and higher polygenic scores for body mass index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our findings replicate some of the known comorbidities of eating disorders on a genomic level and motivate a deeper investigation of shared and unique genomic factors across the three primary eating disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.23481","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T01:00:20Z","timestamp":1614560420000},"page":"785-793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["One size does not fit all. Genomics differentiates among anorexia nervosa, bulimia nervosa, and binge\u2010eating disorder"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1267-8287","authenticated-orcid":false,"given":"Christopher","family":"H\u00fcbel","sequence":"first","affiliation":[{"name":"Social, Genetic &amp; Developmental Psychiatry Centre Institute of Psychiatry, Psychology &amp; Neuroscience, King's College London  London UK"},{"name":"UK National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health South London and Maudsley Hospital  London UK"},{"name":"National Centre for Register\u2010based Research, Aarhus Business and Social Sciences Aarhus University  Aarhus Denmark"},{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6080-257X","authenticated-orcid":false,"given":"Mohamed","family":"Abdulkadir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Gynaecology and Obstetrics, Faculty of Medicine University of Geneva  Geneva Switzerland"},{"name":"Department of Psychiatry, Faculty of Medicine University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3220-5070","authenticated-orcid":false,"given":"Moritz","family":"Herle","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Informatics Institute of Psychiatry, Psychology &amp; Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8532-5087","authenticated-orcid":false,"given":"Ruth J. 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