{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:19:19Z","timestamp":1790770759280,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The persistence of physical exercise in anorexia nervosa (AN) despite underweight and its maintaining factors are poorly understood. The aim of this study was to explore the attitudes toward physical exercise and its effects on emotions, cognitive functioning, and body image perception in patients with AN, and to search for exercise\u2010related endophenotypes of the pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Physical exercise dependence, quantity, and dysregulation were assessed by the Exercise Dependence Scale (EDS), the Godin Leisure Time Exercise Questionnaire (GLTEQ) and a standardized effort test in 88 patients with AN, 30 unaffected relatives and 89 healthy controls. Changes in positive and negative affect, cognitive rigidity, and body image distortion were measured before and after the effort test in the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with AN had higher scores on the EDS and the GLTEQ and used more effort in the standardized effort test. These three measures of physical exercise correlated with negative emotions at baseline. After the effort test, patients with AN had marked emotional improvement, a moderate increase in body image distortion and a small increase in cognitive rigidity compared to HC. Unaffected relatives also had a significant postexercise increase of positive emotion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The mood\u2010related drive for physical exercise has the characteristics of an endophenotype of the disorder. Excessive and driven physical exercise may be state\u2010associated features of AN, driven by the positive effect on emotional wellbeing.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23503","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T13:40:41Z","timestamp":1615556441000},"page":"1181-1188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Physical exercise\u2010related endophenotypes in anorexia nervosa"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0328-338X","authenticated-orcid":false,"given":"Laura","family":"Di Lodovico","sequence":"first","affiliation":[{"name":"Clinique des Maladies Mentales et de l'Enc\u00e9phale H\u00f4pital Sainte\u2010Anne, GHU Paris Psychiatrie et Neurosciences  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Hatteea","sequence":"additional","affiliation":[{"name":"Clinique des Maladies Mentales et de l'Enc\u00e9phale H\u00f4pital Sainte\u2010Anne, GHU Paris Psychiatrie et Neurosciences  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Couton","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, Psychiatrie\u2010Comorbidit\u00e9s\u2010Addictions  Villejuif France"},{"name":"Psychiatry and Addictology Unit, APHP, H\u00f4pitaux Universitaires Paris\u2010Sud  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philibert","family":"Duriez","sequence":"additional","affiliation":[{"name":"Clinique des Maladies Mentales et de l'Enc\u00e9phale H\u00f4pital Sainte\u2010Anne, GHU Paris Psychiatrie et Neurosciences  Paris France"},{"name":"Universit\u00e9 de Paris, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Treasure","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine, Section of Eating Disorders Institute of Psychiatry, Psychology, and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Gorwood","sequence":"additional","affiliation":[{"name":"Clinique des Maladies Mentales et de l'Enc\u00e9phale H\u00f4pital Sainte\u2010Anne, GHU Paris Psychiatrie et Neurosciences  Paris France"},{"name":"Universit\u00e9 de Paris, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2466\/03.27.PMS.120v19x7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20753"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22575"},{"key":"e_1_2_10_6_1","first-page":"249","volume-title":"Psychopathologie quantitative","author":"Criquillon\u2010Doublet S.","year":"1995"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2007.12.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.112703"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31061-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327841mpee0804_1"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(199412)16:4<371::AID-EAT2260160406>3.0.CO;2-W"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(198321)2:2<15::AID-EAT2260020203>3.0.CO;2-6"},{"key":"e_1_2_10_13_1","volume-title":"Eating disorder inventory\u20102: Professional manual","author":"Garner D. 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