{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:23:34Z","timestamp":1789665814961,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Comorbid mental disorders in anorexia nervosa during long\u2010term course require detailed studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This matched cohort study was based on nationwide Danish register data of all patients born 1961\u20132008 with a first\u2010time ICD\u201010 diagnosis of anorexia nervosa (AN) between 1994 and 2018 at age 8\u201332 and matched controls taken from all individuals without an eating disorder (ED). For nine categories of non\u2010eating mental disorders, time from date of first AN\u2010diagnosis (inclusion date) to time of first diagnosis, accounting for censoring, was studied by use of time\u2010stratified Cox models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 9,985 patients with AN (93.5% females) and 49,351 matched controls were followed for a median (IQR) of 9.0 (4.4\u201315.7) years. For patients, there was about 25% and 55% risk of receiving any non\u2010ED disorder during the first 2\u2009years and two decades after inclusion, respectively. A hazard ratio (HR) of seven for any non\u2010ED was found for the first 12\u2009months after inclusion, a ratio that reduced to two at five or more years after inclusion. During the first years, large HRs ranging in 6\u20139 were found for affective, autism spectrum, personality, and obsessive\u2013compulsive disorders with the latter displaying the highest continuous increased risk. The HR at 12\u2009months after inclusion was highest for any non\u2010ED disorder and affective disorders in patients aged 8\u201313 at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Comorbid mental disorders in AN are most frequently diagnosed in the first years after diagnosis of AN and on longer terms imply a double immediate risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23570","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T06:59:05Z","timestamp":1624085945000},"page":"1608-1618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Comorbid mental disorders during long\u2010term course in a nationwide cohort of patients with anorexia 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