{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:46:19Z","timestamp":1772772379721,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/132"],"award-info":[{"award-number":["PI20\/132"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/01167"],"award-info":[{"award-number":["PI17\/01167"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Research suggests abnormalities in reward\u2010based processes in anorexia nervosa (AN). However, few studies have explored if such alterations might be associated with different temporal activation patterns. This study aims to characterize alterations in time\u2010dependent processes in the ventral striatum (VS) during social feedback in AN using functional magnetic resonance imaging (fMRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Twenty women with restrictive\u2010subtype AN and 20 age\u2010matched healthy controls (HC) underwent a social judgment experimental fMRI task. Temporal VS hemodynamic responses were extracted in SPM for each participant and each social condition (acceptance\/rejection).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with age\u2010matched HC, patients with AN showed a significant time by group interaction of peak VS response throughout the task, with a progressive blunting of peak activation responses, accompanied by a progressive increase in baseline activity levels over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The results suggest an attenuated response pattern to repetitive social rejection in the VS in patients with AN, together with a difficulty in returning to baseline. The information obtained from this study will guide future, design\u2010specific studies to further explore alterations temporal dynamics.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23604","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T13:05:30Z","timestamp":1630933530000},"page":"1881-1886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tracking temporal response dynamics in the ventral striatum during social feedback in anorexia nervosa: A functional magnetic resonance imaging exploratory study"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0439-7936","authenticated-orcid":false,"given":"Sonia","family":"Membrives","sequence":"first","affiliation":[{"name":"Department of Mental Health Parc Taul\u00ed\u2010University Hospital of Sabadell  Sabadell Spain"},{"name":"Department of Psychiatry and Forensic Medicine Autonomous University of Barcelona  Barcelona Spain"},{"name":"Mental Health Networking Biomedical Research Centre (CIBERSAM)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"L\u00f3pez\u2010Sol\u00e0","sequence":"additional","affiliation":[{"name":"Serra Hunter Programme, Department of Medicine School of Medicine and Health Sciences, University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Fern\u00e1ndez\u2010Aranda","sequence":"additional","affiliation":[{"name":"Bellvitge University Hospital, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge IDIBELL  Barcelona Spain"},{"name":"Carlos III Health Institute, Obesity and Nutrition Biomedical Research Centre (CIBEROBN)  Barcelona Spain"},{"name":"Department of Clinical Sciences, School of Medicine and Health Sciences University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Bellvitge University Hospital, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge IDIBELL  Barcelona Spain"},{"name":"Carlos III Health Institute, Obesity and Nutrition Biomedical Research Centre (CIBEROBN)  Barcelona Spain"},{"name":"Department of Clinical Sciences, School of Medicine and Health Sciences University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Mart\u00ednez\u2010Zalaca\u00edn","sequence":"additional","affiliation":[{"name":"Bellvitge University Hospital, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge IDIBELL  Barcelona Spain"},{"name":"Carlos III Health Institute, Obesity and Nutrition Biomedical Research Centre (CIBEROBN)  Barcelona Spain"},{"name":"Department of Clinical Sciences, School of Medicine and Health Sciences University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Palao","sequence":"additional","affiliation":[{"name":"Department of Mental Health Parc Taul\u00ed\u2010University Hospital of Sabadell  Sabadell Spain"},{"name":"Department of Psychiatry and Forensic Medicine Autonomous University of Barcelona  Barcelona Spain"},{"name":"Mental Health Networking Biomedical Research Centre (CIBERSAM)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Pujol","sequence":"additional","affiliation":[{"name":"Mental Health Networking Biomedical Research Centre (CIBERSAM)  Barcelona Spain"},{"name":"MRI Research Unit, Department of Radiology Hospital del Mar  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose M.","family":"Mench\u00f3n","sequence":"additional","affiliation":[{"name":"Mental Health Networking Biomedical Research Centre (CIBERSAM)  Barcelona 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