{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:16:56Z","timestamp":1789179416787,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH109639"],"award-info":[{"award-number":["R01 MH109639"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anorexia nervosa (AN) usually develops in early adolescence and is characterized by high rates of morbidity and mortality. Family\u2010based therapy (FBT) is the leading evidence\u2010based treatment for adolescents with AN, but not all patients experience sufficient improvement. The purpose of this manuscript is to describe the development and subsequent experience with a Family\u2010Based Interoceptive Exposure (FBT\u2010IE) for adolescents with a broader form of low\u2010weight eating disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The novel IE\u2010based behavioral intervention is a six\u2010session family\u2010based treatment module designed to directly target and modify disgust by altering the prefrontal regulation of the insula response to aversive stimuli by decreasing visceral sensitivity (e.g., bloating). Each session teaches a new skill regarding tolerating distress to visceral sensations associated with disgust and an in\u2010vivo \u201cIE exercise,\u201d in which the family is provided with a meal replacement shake of unknown content and caloric density.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this novel treatment, the patient learns to tolerate disgust in the context of a challenging food stimulus as a way to increase consumption of restricted foods outside of session.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We discuss successes and challenges executing this treatment with patients with low\u2010weight eating disorders and propose future directions for the intervention.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23605","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T06:18:30Z","timestamp":1631773110000},"page":"2037-2045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Lessons learned developing and testing <scp>family\u2010based<\/scp> interoceptive exposure for adolescents with l<scp>ow\u2010weight<\/scp> eating disorders"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7054-9590","authenticated-orcid":false,"given":"Tom","family":"Hildebrandt","sequence":"first","affiliation":[{"name":"Eating and Weight Disorders Program, Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2012-5364","authenticated-orcid":false,"given":"Deena","family":"Peyser","sequence":"additional","affiliation":[{"name":"Eating and Weight Disorders Program, Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3381-986X","authenticated-orcid":false,"given":"Robyn","family":"Sysko","sequence":"additional","affiliation":[{"name":"Eating and Weight Disorders Program, Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90557-9"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.1025"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/02699931.2020.1736992"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0034558"},{"issue":"3","key":"e_1_2_5_6_1","first-page":"802","article-title":"Behavioral conception and treatment of panic","volume":"22","author":"Barlow D. 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