{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:58:41Z","timestamp":1792112321448,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012129","name":"Baker Foundation","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100012129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Stepped\u2010care models of treatment are underexplored in eating disorders. To enhance treatment outcomes, and informed by literature about adaptations to family\u2010based treatment (FBT), we developed an FBT\u2010based stepped\u2010care model for adolescents with anorexia nervosa (AN) that was consistent with family preference (i.e., tailored) and responsive to adolescent needs (i.e., intensity). The aim of this study was to evaluate the effectiveness of this model in terms of remission at end\u2010of\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Adolescents (<jats:italic>N<\/jats:italic>\u00a0=\u00a082), aged 12\u201318\u2009years (M\u00a0=\u00a015.1, <jats:italic>SD<\/jats:italic>\u00a0=\u00a01.8) and meeting Diagnostic and Statistical Manual of Mental Disorders 5th Edition criteria for AN, were assessed at baseline, Weeks 24 and 48. FBT was tailored to family preference and clinical need, with 16\u201318 sessions by Week 24. This was followed by three FBT booster sessions or an extension of FBT plus booster sessions (Week 48). The primary outcome was defined as weight\u00a0&gt;\u200995% of %median body mass index plus within 1\u2009<jats:italic>SD<\/jats:italic> of the Eating Disorder Examination (EDE) global score community norms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Remission rates were 45.1% and 52.4% at Weeks 24 and 48, respectively. Commensurable improvements were evident across secondary outcomes (e.g., EDE subscale scores). As a reference point, remission rates compared positively with results from a recent randomized clinical trial from the same center and at the same time points (Week 24:45.1% vs. 32.1% and Week 48:52.4% vs. 30.2%). Controlling for propensity score, no statistically significant differences were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This stepped\u2010care model, designed to be responsive to the individual needs of adolescents and their families, achieved encouraging rates of remission. This study provides an important signal that supports future clinical trials of stepped\u2010care models for adolescents with AN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23629","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T09:39:53Z","timestamp":1634895593000},"page":"1989-1997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Family\u2010based treatment for adolescent anorexia nervosa: Outcomes of a stepped\u2010care model"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7293-9496","authenticated-orcid":false,"given":"Daniel","family":"Le Grange","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California  San Francisco California USA"},{"name":"Department of Psychiatry and Behavioral Neuroscience The University of Chicago  Chicago Illinois USA (Emeritus)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Pradel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Royal Children's Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Pogos","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Royal Children's Hospital  Melbourne Australia"},{"name":"Murdoch Children's Research Institute  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Royal Children's Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4377-5610","authenticated-orcid":false,"given":"Elizabeth K.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute  Melbourne Australia"},{"name":"Department of Pediatrics The University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Tompson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Royal Children's Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Court","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Royal Children's Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross D.","family":"Crosby","sequence":"additional","affiliation":[{"name":"Sanford Center for Bio\u2010Behavioral Research  Fargo North Dakota USA"},{"name":"Department of Psychiatry and Behavioral Science University of North Dakota School of Medicine and Health Sciences  Fargo North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan 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