{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:08:46Z","timestamp":1790752126492,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010586","name":"Haukeland University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004257","name":"Helse Vest","doi-asserted-by":"publisher","award":["912177"],"award-info":[{"award-number":["912177"]}],"id":[{"id":"10.13039\/501100004257","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There is no conclusive evidence for involvement of intestinal barrier alteration in the etiology of anorexia nervosa (AN). The aims of this pilot study were to identify serum markers of intestinal barrier integrity in patients with AN and to determine the relationships between those markers and body mass index (BMI), eating disorder symptoms, gastrointestinal complaints, and liver synthesis function (international normalized ratio [INR]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Twenty\u2010five outpatients with AN prior to starting treatment and 28 healthy controls (HC) were assessed. BMI and serum markers of intestinal barrier integrity were measured, including zonulin family peptides (ZFP), lipopolysaccharide\u2010binding protein (LBP), and intestinal fatty\u2010acid\u2010binding protein (i\u2010FABP). Eating disorder symptoms and gastrointestinal complaints were evaluated via questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The serum ZFP concentration was significantly lower in patients with AN than in HC (44.2 [7.4] vs. 49.2 [5.6] ng\/ml, mean [standard deviation], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.008). LBP and i\u2010FABP did not differ between the two groups. In patients with AN, serum ZFP was significantly predicted by BMI (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.479, <jats:italic>p\u00a0=\u00a0<\/jats:italic>.009), age (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.411, <jats:italic>p\u00a0=\u00a0<\/jats:italic>.020), and INR (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.388, <jats:italic>p\u00a0=\u00a0<\/jats:italic>.028). No such associations were found for either gastrointestinal complaints or eating disorder symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Abnormal levels of serum ZFP were observed in patients with AN. Further studies with other assessment methods are warranted to examine intestinal barrier function in AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> Identifier: NCT02745067.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23678","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T06:20:53Z","timestamp":1642486853000},"page":"703-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Intestinal barrier integrity in anorexia nervosa (a pilot study)"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3036-2323","authenticated-orcid":false,"given":"Malin M.","family":"Kleppe","sequence":"first","affiliation":[{"name":"Department of Psychiatry Haukeland University Hospital  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg","family":"Br\u00f8nstad","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Haukeland University Hospital  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclen A.","family":"Lied","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Haukeland University Hospital  Bergen Norway"},{"name":"Center for Nutrition, Department of Clinical Medicine University of Bergen  Bergen Norway"},{"name":"National Center for Functional Gastrointestinal Disorders, Medical Department Haukeland University Hospital  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yngvild","family":"Danielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guro \u00c5.","family":"Rekkedal","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Haukeland University Hospital  Bergen Norway"},{"name":"Department of Clinical Psychology University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2002-5518","authenticated-orcid":false,"given":"Ute","family":"Kessler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Haukeland University Hospital  Bergen Norway"},{"name":"Department of Clinical Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-020-00594-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2008.06.012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yclnex.2019.05.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.116.131110"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-1056-6"},{"key":"e_1_2_8_7_1","volume-title":"Statement on zonulin measurement with the immundiagnostik ELISA","author":"Dschietzig T. 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