{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:05:47Z","timestamp":1772118347122,"version":"3.50.1"},"reference-count":75,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Identifying risk factors that contribute to the development of anorexia nervosa (AN) is critical for the implementation of early intervention strategies. Anxiety, obsessive\u2013compulsive behavior, and immune dysfunction may be involved in the development of AN; however, their direct influence on susceptibility to the condition remains unclear. Here, we used the activity\u2010based anorexia (ABA) model to examine whether activity, anxiety\u2010like behavior, compulsive behavior, and circulating immune markers predict the subsequent development of pathological weight loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Female Sprague\u2013Dawley rats (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200944) underwent behavioral testing before exposure to ABA conditions after which they were separated into susceptible and resistant subpopulations. Blood was sampled before behavioral testing and after recovery from ABA to screen for proinflammatory cytokines.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Rats that were vulnerable to pathological weight loss differed significantly from resistant rats on all key ABA parameters. While the primary measures of anxiety\u2010like or compulsive behavior were not shown to predict vulnerability to ABA, increased locomotion and anxiety\u2010like behavior were both associated with the\n                      <jats:italic>extent of<\/jats:italic>\n                      weight loss in susceptible but not resistant animals. Moreover, the change in expression of proinflammatory markers IL\u20104 and IL\u20106 evoked by ABA was associated with discrete vulnerability factors. Intriguingly, behavior related to risk assessment was shown to predict vulnerability to ABA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>We did not find undisputable behavioral or immune predictors of susceptibility to pathological weight loss in the ABA rat model. Future research should examine the role of cognition in the development of ABA, dysfunction of which may represent an endophenotype linking anorectic, anxiety\u2010like and compulsive behavior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Public Significance<\/jats:title>\n                    <jats:p>Anorexia nervosa (AN) has among the highest mortality rates of all psychiatric disorders and treatment options remain limited in their efficacy. Understanding what types of risk factors contribute to the development of AN is essential for implementing early intervention strategies. This study describes how some of the most common psychological features of AN could be used to predict susceptibility to pathological weight loss in a well\u2010established animal model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.23705","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T06:04:13Z","timestamp":1647583453000},"page":"664-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["In pursuit of biomarkers for predicting susceptibility to activity\u2010based anorexia in adolescent female rats"],"prefix":"10.1002","volume":"55","author":[{"given":"Laura Karina","family":"Milton","sequence":"first","affiliation":[{"name":"Department of Physiology Monash University  Clayton Victoria Australia"},{"name":"Monash Biomedicine Discovery Institute  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9642-7003","authenticated-orcid":false,"given":"Timothy","family":"Patton","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Monash University  Clayton Victoria Australia"},{"name":"Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity University of Melbourne  Elizabeth Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith","family":"O'Keeffe","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Monash University  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian John","family":"Oldfield","sequence":"additional","affiliation":[{"name":"Department of Physiology Monash University  Clayton Victoria Australia"},{"name":"Monash Biomedicine Discovery Institute  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3293-8242","authenticated-orcid":false,"given":"Claire Jennifer","family":"Foldi","sequence":"additional","affiliation":[{"name":"Department of Physiology Monash University  Clayton Victoria Australia"},{"name":"Monash Biomedicine Discovery Institute  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2011.04.006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.06.013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.2.242"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.74"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2020.06.030"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.4.563"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep35813"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2021.684936"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20175"},{"issue":"8","key":"e_1_2_9_11_1","first-page":"3980","article-title":"Variant BDNF\u2010Val66Met polymorphism is associated with layer\u2010specific alterations in GABAergic innervation of pyramidal neurons, elevated anxiety and reduced vulnerability of adolescent male mice to activity\u2010based anorexia","volume":"27","author":"Chen Y.\u2010W.","year":"2017","journal-title":"Cerebral Cortex"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23275"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623315570339"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-027925"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.06.002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-018-00653-4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2295"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20834"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2009.09.009"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mgene.2016.12.013"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.16121402"},{"key":"e_1_2_9_22_1","volume-title":"Current Protocols in Neuroscience","author":"File S. 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